Angiogenesis; from basic science to clinical applications.9780849328442 Angiogenesis; from basic science to clinical applications. Ed. by Napoleone Ferrara. CRC / Taylor & Francis 2007 280 pages $149.95 Hardcover QP102 While angiogenesis, the process in which new blood vessels grow from pre-existing vessels is a normal part of growth and development, it also plays a key role in the transition of tumors from dormant to malignant states, prompting researchers to explore the use of anti- angiogenesis agents in therapeutic applications. In this work, Ferrara (Genentech, Inc.) presents examples of recent work in the field, looking at advances in the basic science and in clinical studies with inhibitors of angiogenesis. Particular topics covered by the 13 chapters include pathophysiology and clinical implications of vascular endothelial growth factor Vascular endothelial growth factor (VEGF) is an important signaling protein involved in both vasculogenesis (the de novo formation of the embryonic circulatory system) and angiogenesis (the growth of blood vessels from pre-existing vasculature). (VEGF-a signaling protein), signal transduction of VEGF receptors toward angiogenesis, growth factors and lymphangiogenesis, neural guidance molecules in vascular development, non-angiogenic functions of VEGF VEGF vascular endothelial growth factor. , contribution of pro-angiogenic hematopoietic cells to vascularization vascularization /vas·cu·lar·iza·tion/ (vas?ku-ler-i-za´shun) 1. the process of becoming vascular. 2. angiogenesis. 3. the surgically induced development of vessels in a tissue. of tumor and ischemic Ischemic An inadequate supply of blood to a part of the body, caused by partial or total blockage of an artery. Mentioned in: Antiangiogenic Therapy, Subarachnoid Hemorrhage, Ventricular Fibrillation ischemic tissues, antiangiogenic an·ti·an·gi·o·gen·ic adj. Inhibiting the growth of blood vessels. antiangiogenic drugs as broadly effective chemosensitizing agents, ocular neovascularization, and therapeutic angiogenesis for cardiovascular disease. ([c]20062005 Book News, Inc., Portland, OR) |
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