Angiogenesis; biology and pathology.

9781936113439

Angiogenesis; biology and pathology.

Ed. by Michael Klagsbrun and Patricia A. D'Amore.

Cold Spring Harbor Lab. Press

2012

522 pages

$135.00

Hardcover

A subject collection from Cold Springs Harbor perspectives in medicine

QP106

For developmental and cancer biologists, Klagsbrun and D'Amore (Harvard Medical School) compile 30 chapters on the mechanisms of angiogenesis that operate in normal development and in diseases such as cancer, focusing on the most important advances. Researchers working in vascular biology, pathology, physiology, oncology, and other areas in the US, Europe, and Israel discuss the biology of endothelial cells; vessel formation and patterning and lumen formation, including the roles and regulation of tip and stalk cells in vessel sprouting; developmental angiogenesis in zebrafish; endothelial stem cells, microRNAs, and endothelial-neural interactions; and the differences between tumor endothelial cells (ECs) and normal cells. They describe comparison of the regulation of lymphatic and blood vessel development; key molecular regulators of angiogenesis; antiangiogenic agents such as thrombospondins and semaphorins; the role of the tumor microenvironment; blood vessel normalization for facilitating drug delivery; vascular pathologies such as hemangiomas, preeclampsia, and arteriovenous malformation, as well as the role of polymorphisms, integrins, and disruption of EC-EC junctions; and a critique of anti-vascular endothelial growth factor (VEGF) therapy, based on clinical trial information.

([c]2012 Book News, Inc., Portland, OR)