AnaSpec Launches the EnzoLyte(TM) 520 Renin Assay Kit with Ultra-High Sensitivity.SAN JOSE, Calif. -- The past decade has witnessed the development of a number of synthetic renin renin /re·nin/ (re´nin) a proteolytic enzyme synthesized, stored, and secreted by the juxtaglomerular cells of the kidney; it plays a role in regulation of blood pressure by catalyzing the conversion of angiotensinogen to angiotensin I. inhibitors1-3. However, increasing demand for accelerated drug discovery and automated inhibitor screening has generated a need for a continuous, homogeneous assay with even greater sensitivity. With the introduction of the ultra-sensitive EnzoLyte(TM )520 Renin Assay Kit, AnaSpec now offers a renin assay kit that is 40x more sensitive than comparable kits currently in the market. Renin, a highly specific aspartyl protease, cleaves angiotensinogen, to yield angiotensin I, which is further converted into angiotensin II by ACE (Angiotensin Converting Enzyme Noun 1. angiotensin converting enzyme - proteolytic enzyme that converts angiotensin I into angiotensin II angiotensin-converting enzyme, ACE peptidase, protease, proteinase, proteolytic enzyme - any enzyme that catalyzes the splitting of proteins into ). Angiotensin II constricts blood vessels, leading to increased blood pressure. Angiotensin II also increases the secretion of ADH ADH: see antidiuretic hormone. and aldosterone, and stimulates the hypothalamus hypothalamus (hī'pəthăl`əməs), an important supervisory center in the brain, rich in ganglia, nerve fibers, and synaptic connections. It is composed of several sections called nuclei, each of which controls a specific function. to activate the thirst reflex. Since an overactive o·ver·ac·tive adj. Active to an excessive or abnormal degree: an overactive child. o renin-angiotensin system leads to hypertension, renin is an attractive target for the treatment of this disease. While existing renin assay kits offer sub-nanomolar potency and selectivity, AnaSpec's EnzoLyte(TM) 520 Renin Assay Kit offers picomolar sensitivity - the highest sensitivity available for commercial renin assay kits. AnaSpec also offers a shorter emission wavelength kit, EnzoLyte[TM] 390 Renin Assay Kit - a cost-effective option that offers greater sensitivity than EDANS/DABCYL-based renin assay kits. EnzoLyte[TM] 520 Renin Assay Kit (http://www.anaspec.com/products/product.asp?id=33273) EnzoLyte[TM] 390 Renin Assay Kit (http://www.anaspec.com/products/product.asp?id=33272) [TABLE OMITTED] For more information, visit www.anaspec.com AnaSpec, Inc., located in San Jose, CA, is a leading provider of integrated proteomics solutions to pharmaceutical, biotech, and academic research institutions throughout the world. With a vision for innovation through synergy, AnaSpec focuses on three core technologies: peptides, detection reagents, and combinatorial chemistry. AnaSpec carries a broad product line of biochemicals and reagents for basic research, high-throughput screening and drug discovery. In conjunction, AnaSpec provides premier custom services including peptide synthesis, antibody production, and assay development. Established in 1993, AnaSpec's headquarters and manufacturing facilities are located in San Jose, CA. AnaSpec maintains ISO (1) See ISO speed. (2) (International Organization for Standardization, Geneva, Switzerland, www.iso.ch) An organization that sets international standards, founded in 1946. The U.S. member body is ANSI. 9001 certification, holds a California Drug Manufacturing License and a FDA FDA abbr. Food and Drug Administration FDA, n.pr See Food and Drug Administration. FDA, n.pr the abbreviation for the Food and Drug Administration. Registration for GMP GMP (guanosine monophosphate): see guanine. Drug Manufacturing. References: 1. Wood, JM. et al., Hypertension, 7, 797 (1985). 2. Shibasaki, M. et al., Am. J. Hypertens. 4, 932 (1991). 3. Wood, JM. et al., Biochem. Biophys. Res. Comm. 308, 698 (2003). |
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