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An "Expression of Hope" from the afflicted.


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"I am ten years old and have MPS I. My painting of a dragon expresses the courage that everyone needs when they have MPS." Artist Nicklas Harkins describes his life with Mucopolysaccharidosis I and his strength, along with the stories of others living with lysosomal lysosomal

pertaining to or emanating from lysosomes.


lysosomal enzymes
enzymes located in the lysosomes.

lysosomal phospholipidosis
 storage disorders (LSDs), through a collection of inspiring pieces of art entitled "Expression of Hope."

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Lysosomal storage disorders are a group of approximately 50 inherited genetic disorders The following is a list of genetic disorders and their origins. Beside most disorders is a code that indicates the type of fertilization and the chromosome involved.
  • P - Point mutation, or any insertion/deletion entirely inside one gene
, sharing common clinical and biochemical characteristics. Individually, each disease is rare but, as a group, the prevalence of LSDs has been estimated from one in 5,000 to one in 7,000 individuals.

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People with LSDs either are lacking--or in short supply of--particular enzymes that are found in the lysosome lysosome

Membrane-enclosed organelle found in all eukaryotic cells (see eukaryote) that is responsible for the cell's digestion of macromolecules, old cell parts, and microorganisms.
 (a compartment of the cell) that contains various digestive enzymes Digestive enzymes
Molecules that catalyze the breakdown of large molecules (usually food) into smaller molecules.

Mentioned in: Heartburn

digestive enzymes
 as well as acidic materials. Because of this, molecules that are meant to be broken down by the missing enzymes build up within the lysosome and can prevent the cell from working properly. Most LSDs are progressive and life threatening.

Sponsored by the biotechnology company Genzyme, the artwork featured in "Expression of Hope" were created as a means to generate awareness and understanding of the strength and courage of thousands of people worldwide living with LSDs. After the exhibition closes March 2 at the National Museum of Health and Medicine, Washington, D.C., its contents will go on permanent display at Genzyme's facility in Massachusetts.

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COPYRIGHT 2008 Society for the Advancement of Education
No portion of this article can be reproduced without the express written permission from the copyright holder.
Copyright 2008 Gale, Cengage Learning. All rights reserved.

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Title Annotation:exhibition of stories and art of people with Lysosomal Storage Disorders
Publication:USA Today (Magazine)
Article Type:Brief article
Geographic Code:1USA
Date:Feb 1, 2008
Words:245
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