Amgen Oncology Highlights Upcoming Data Presentations at the American Society of Clinical Oncology Annual Meeting; Clinical Data to be Presented on Four Investigational Targeted Cancer Therapies.

THOUSAND OAKS, Calif. -- Amgen (NASDAQ:AMGN), the world's largest biotechnology company, today announced upcoming data presentations at the 42nd Annual Meeting of the American Society of Clinical Oncology (ASCO) in Atlanta. Clinical results will be presented on four investigational cancer therapies: panitumumab in metastatic colorectal cancer patients, denosumab in breast cancer patients with bone metastases, AMG 706 in advanced thyroid cancer patients, and recombinant human Apo2L/TRAIL (co-developed with Genentech, Inc.) in patients with advanced cancer. In addition, updated data evaluating every-three-week administration of darbepoetin alfa for the treatment of anemia associated with myelodysplastic syndromes (MDS), and in combination with iron for the treatment of chemotherapy-induced anemia, will be presented.

"At Amgen, we take a comprehensive approach to helping patients in their fight against cancer. From our strong foundation in supportive care to our entry into innovative therapeutics, Amgen researchers are constantly evaluating new pathways and modalities for developing novel treatments," said Willard Dere, M.D., chief medical officer and senior vice president of Global Development. "We are very excited to present new data on multiple agents from our robust pipeline of investigational targeted therapies."

The following are selected studies of interest being presented on Amgen's investigational compounds and marketed products this year at ASCO:

Panitumumab

--  Panitumumab antitumor activity in patients with metastatic
    colorectal cancer expressing low (less than 1-9 percent) or
    negative (less than 1 percent) levels of epidermal growth factor
    receptor

    Abstract #3547 (Saturday, June 3, 8:00 a.m. - 12:00 p.m., Bldg B,
    Level 1, Hall B5)

--  Panitumumab antitumor activity in patients with metastatic
    colorectal cancer expressing greater than 10 percent epidermal
    growth factor receptor

    Abstract #3548 (Saturday, June 3, 8:00 a.m. - 12:00 p.m., Bldg B,
    Level 1, Hall B5)

Denosumab

--  Randomized, active-controlled study of denosumab (AMG 162) in
    breast cancer patients with bone metastases not previously treated
    with intravenous (IV) bisphosphonates (BP)

    Abstract #512 (Sunday, June 4, 9:15 a.m. - 9:30 a.m., Bldg C,
    Level 1, Hall C1, Oral Presentation)

--  A randomized trial of denosumab (AMG 162) versus intravenous (IV)
    bisphosphonates (BP) in cancer patients (Pts) with bone metastases
    (BM) on established IV BP and evidence of elevated bone resorption

    Abstract #8562 (Saturday, June 3, 2:00 p.m. - 6:00 p.m., Bldg B,
    Level 1, Hall B5)

AMG 706

--  Safety and antitumor activity of AMG 706 in patients with thyroid
    cancer: A subset analysis from a Phase 1 dose-finding study

    Abstract #3030 (Saturday, June 3, 8:00 a.m. - 12:00 p.m., Bldg C,
    Level 3, Room C306)

Recombinant Human Apo2L/TRAIL

--  A Phase 1 safety and pharmacokinetic study of recombinant
    Apo2L/TRAIL, an apoptosis-inducing protein in patients with
    advanced cancer

    Abstract #3013 (Saturday, June 3, 3:00 p.m. - 3:15 p.m., Bldg B,
    Level 3, Room B305)

Darbepoetin alfa

--  A randomized open-label study of darbepoetin alfa administered
    every 3 weeks with or without parenteral iron in anemic subjects
    with nonmyeloid malignancies receiving chemotherapy

    Abstract #8612 (Saturday, June 3, 2:00 p.m. - 6:00 p.m., Bldg B,
    Level 1, Hall B5)

--  Darbepoetin alfa for treating anemia in low-risk myelodysplastic
    syndrome patients: Interim results after 27/28 weeks

    Abstract #6564 (Saturday, June 3, 8:00 a.m. - 12:00 p.m., Bldg B,
    Level 1, Hall B5)

--  Darbepoetin alfa for treating anemia in patients with low-risk
    myelodysplastic syndromes: Exploratory analysis of baseline
    predictors of response

    Abstract #6579 (Saturday, June 3, 8:00 a.m. - 12:00 p.m., Bldg B,
    Level 1, Hall B5)

Aranesp(R) (darbepoetin alfa) has not been approved by the Food and Drug Administration (FDA) for the treatment of anemia associated with myelodysplastic syndromes. Aranesp is contraindicated in patients with uncontrolled hypertension. Erythropoietic therapies may increase the risk of thrombotic events and other serious events.

Webcast Information

Amgen will host a webcast with the investment community on Sunday, June 4th, at 6:00 p.m. EDT to discuss data presented at ASCO. Open to members of the news media, investors and the general public, the webcast can be found on Amgen's Web site, www.amgen.com, under Investors. It will be archived and available for replay at least 72 hours after the event.

About Amgen

Amgen discovers, develops and delivers innovative human therapeutics. A biotechnology pioneer since 1980, Amgen was one of the first companies to realize the new science's promise by bringing safe and effective medicines from lab, to manufacturing plant, to patient. Amgen therapeutics have changed the practice of medicine, helping millions of people around the world in the fight against cancer, kidney disease, rheumatoid arthritis, and other serious illnesses. With a broad and deep pipeline of potential new medicines, Amgen remains committed to advancing science to dramatically improve people's lives. To learn more about our pioneering science and our vital medicines, visit www.amgen.com.

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