Amgen's Oncology Pipeline Data Highlighted at Upcoming Scientific Meeting.

Five Investigational Compounds from Robust Ongoing Clinical Trials Program Target Novel Cancer Pathways

THOUSAND OAKS, Calif. -- Amgen (NASDAQ: AMGN) today announced that results from several preclinical and clinical trials investigating cancer treatment will be presented at the American Association for Cancer Research (AACR) Annual Meeting 2008 in San Diego between April 12-16, 2008. Data will be presented on pipeline compounds: AMG 102, AMG 386, AMG 479, AMG 655 and motesanib diphosphate (AMG 706).

At AACR, Amgen will present data from studies investigating the tumor attacking potential of these products - alone or in combination with other therapies. These early studies have provided the biologic evidence to allow Amgen to launch a suite of exploratory Phase 1b/2 programs with these five molecules, across 15 tumor types with more than 30 clinical trials currently underway or planned.

"These data underscore our ongoing exploration of key biological processes that influence the growth of cancer cells including angiogenesis, apoptosis and growth regulation," said David Chang, M.D., vice president, Global Oncology Development at Amgen. "In addition, Amgen is actively pursuing identification of biomarkers that will help the company make better and earlier decisions about pipeline compounds, and enable targeted application of specific therapies to the patients who are more likely to benefit from treatment with them."

Selected Presentations of Interest

Anti-Angiogenesis

A program focused on the development of molecules that will interdict the abnormal process of new blood vessel formation.

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Cancer Cell Apoptosis

A program focused on the development of highly selective therapies to induce cancer cell death (apoptosis).

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Growth Regulation

A program focused on targeting cellular pathways that regulate cell pre-production, survival, migration and invasion which cancer cells often escape.

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About Amgen

Amgen discovers, develops, manufactures and delivers innovative human therapeutics. A biotechnology pioneer since 1980, Amgen was one of the first companies to realize the new science's promise by bringing safe and effective medicines from lab, to manufacturing plant, to patient. Amgen therapeutics have changed the practice of medicine, helping millions of people around the world in the fight against cancer, kidney disease, rheumatoid arthritis and other serious illnesses. With a deep and broad pipeline of potential new medicines, Amgen remains committed to advancing science to dramatically improve people's lives. To learn more about our pioneering science and our vital medicines, visit www.amgen.com.

Forward-Looking Statements

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