American Diabetes Association and Entelos Announce Launch of Realab for Type 1 Diabetes.ALEXANDRIA, Va. & FOSTER CITY, Calif. -- The American Diabetes Association The American Diabetes Association, or the ADA, is an American health organization providing diabetes research, information and advocacy. Founded in 1940, the American Diabetes Association conducts programs in all 50 states and the District of Columbia, reaching hundreds of (ADA Ada, city, United States Ada (ā`ə), city (1990 pop. 15,820), seat of Pontotoc co., S central Okla.; inc. 1904. It is a large cattle market and the center of a rich oil and ranch area. ) and Entelos, Inc. (LSE LSE - Language Sensitive Editor :ENTL ENTL Entitle(d) ) announced today the launch of Realab, a new simulation tool that provides direct web access to Entelos' state-of-the-art computer model of type 1 diabetes type 1 diabetes n. See diabetes mellitus. , allowing scientists and clinicians an unparalleled ability to investigate the onset, progression, and treatment of diabetes. Using Realab, researchers can conduct simulations on drugs, drug combinations, dose levels, dosing regimens, therapeutic targets, biological pathways and functions using the primary animal model used to study type 1 diabetes. Once a Realab protocol is submitted, simulation results are available within 24 hours. Realab includes menus that facilitate the design and submission of virtual experiments and clinical protocols. The ADA and Entelos collaborated to develop the Type 1 Diabetes PhysioLab([R]) platform, a large scale computer-based mathematical model
"The ADA is committed to finding new treatments and, ultimately, a cure for diabetes," said Richard Kahn, Ph.D., chief scientific and medical officer, American Diabetes Association. "Realab will help researchers by providing them with direct access to Entelos' cutting-edge simulation technology via the web and make a big impact on both preclinical and clinical programs in type 1 diabetes, which primarily affects children and young adults. We are excited to unveil this innovative approach to finding better therapies in partnership with Entelos." "Entelos has been developing Realab for over a year with the goal of increasing access to Entelos' state-of-the-art in silico models of human and animal disease physiology," stated James Karis, president and CEO (1) (Chief Executive Officer) The highest individual in command of an organization. Typically the president of the company, the CEO reports to the Chairman of the Board. of Entelos. "We believe our predictive disease models and virtual patients and virtual mice can help enhance understanding of complex diseases such as type 1 diabetes; and, more importantly, help translate results from animal experiments to create successful medicines for patients. Realab can be an important stepping stone for researchers and clinicians and serve as an introduction to the power of Entelos' simulation technology. We envision a day when all researchers will have access to the power of simulation to enhance their research capability." Realab currently has a virtual environment available for type 1 diabetes. Environments for rheumatoid arthritis rheumatoid arthritis Chronic, progressive autoimmune disease causing connective-tissue inflammation, mostly in synovial joints. It can occur at any age, is more common in women, and has an unpredictable course. , cardiovascular disease Cardiovascular disease Disease that affects the heart and blood vessels. Mentioned in: Lipoproteins Test cardiovascular disease and type 2 diabetes type 2 diabetes n. See diabetes mellitus. are under development by Entelos. Details regarding Realab can be found at http://realab.entelos.com. Notes to Editors About Realab Realab was developed by Entelos Inc., the leader in predictive biosimulation, to provide scientists and clinicians with personalized web-based access to Entelos' award-winning PhysioLab[R] technology and computer models of human and animal disease physiology. Realab's virtual environments allow investigators to preview the likely effects of different therapeutic interventions in advance, helping to inform the optimal design of research and clinical protocols in the real world. The Realab web-based tool facilitates the design and submission of experiments and clinical protocols. The investigator uses a menu system to select from available predefined options for each simulation analysis (language, simulation) SIMulation ANalysis - (SIMAN) A simulation language, especially for manufacturing systems, developed by C. Dennis Pegden in 1983. ["Introduction to Simulation using SIMAN", C.D. Pegden et al, McGraw-Hill 1990]. including drugs, drug combinations, dose levels, dosing regimens, therapeutic targets, biological pathways, functions, patient or animal phenotypes and sampling intervals. Once a Realab protocol is submitted, simulation results are available in Realab within 24 hours for later analysis at the user's convenience. Researchers can visualize the predicted outcome of the Realab protocol using graphs and other tools to investigate the underlying biological mechanisms responsible for each predicted outcome. Realab currently has a virtual environment available for type 1 diabetes with predefined experiments, about a dozen therapies and 75 possible model outputs. Environments for rheumatoid arthritis, cardiovascular disease and type 2 diabetes are under development by Entelos. Access to Realab simulations can be purchased online or via purchase order. About the Type 1 Diabetes PhysioLab Platform The Entelos[R] Type 1 Diabetes PhysioLab[R] platform is a large-scale, mathematical model of the non-obese diabetic (NOD) mouse designed to support research in type 1 diabetes. The platform captures the physiology of pancreatic cell autoimmunity and tolerance from birth until disease onset. Virtual NOD mice are constructed using equations that mathematically represent cellular functions and biochemical interactions in tissues critical for the pathogenesis of type 1 diabetes. The model encompasses two main tissues: pancreatic lymph nodes Lymph nodes Small, bean-shaped masses of tissue scattered along the lymphatic system that act as filters and immune monitors, removing fluids, bacteria, or cancer cells that travel through the lymph system. (PLN PLN In currencies, this is the abbreviation for the Polish Zloty. Notes: The currency market, also known as the Foreign Exchange market, is the largest financial market in the world, with a daily average volume of over US $1 trillion. ) and pancreatic islets pancreatic islets Islets of Langerhans Anatomy Clusters of cells in the pancreas that form the endocrine portion and secrete insulin and glucagon . Antigen and antigen-presenting cells traffic from the islets to the PLN, and conversely, lymphocytes Lymphocytes Small white blood cells that bear the major responsibility for carrying out the activities of the immune system; they number about 1 trillion. activated in the PLN can enter the blood and be recruited to the islets. Functions at the biochemical and cellular levels are integrated and the dynamic relationships over time quantitatively linked via mathematical equations, making simulation and prediction of biological outcomes possible. About Entelos Entelos, Inc. (www.entelos.com) is a life sciences company applying next-generation predictive technologies and using "virtual patients" to revolutionize the way medicines are discovered, developed, and utilized. The Company's core biosimulation computer models, known as PhysioLab[R] platforms, are used to validate novel drug targets, select and develop compounds, assess safety, optimize clinical trials and combination therapies, reprofile drugs, evaluate in-licensing candidates, and better position existing products in competitive markets. In addition to internal programs, Entelos partners with global pharmaceutical and biotechnology companies and currently provides scientific expertise and models in such areas as cardiovascular disease, asthma, obesity, diabetes and rheumatoid arthritis, and such complex physiological processes as hematopoiesis Hematopoiesis The process by which the cellular elements of the blood are formed. The three main types of cells are the red cells (erythrocytes), which serve to carry oxygen, the white cells (leukocytes), which function in the prevention of and recovery from (anemia), cholesterol metabolism, and skin sensitization skin sensitization, n an allergic reaction to a particular irritant that results in the development of skin inflammation and itchiness. Unlike skin irritation, the skin becomes increasingly reactive to the substance as a result of subsequent exposures. . About the American Diabetes Association The American Diabetes Association (www.diabetes.org) is the nation's premier voluntary health organization supporting diabetes research, information and advocacy. Founded in 1940, the Association has offices in every region of the country, providing services to hundreds of communities. The Association's commitment to research is reflected through its scientific meetings; education and provider recognition programs; and its Research Foundation and Nationwide Research Program, which fund breakthrough studies looking into the cure, prevention, and treatment of diabetes and its complications. For more information, please visit www.diabetes.org or call 1-800-DIABETES (1-800-342-2383). Information from both these sources is available in English and Spanish. |
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