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AmCyte Presents Adult Stem Cell Regenerated Islet Data at the 44th Annual Meeting of the American Society for Cell Biology.


LOS ANGELES -- AmCyte Inc. (www.amcyte.com), a leader in encapsulated islet islet /is·let/ (-lit) an island.

islets of Langerhans  irregular microscopic structures scattered throughout the pancreas and comprising its endocrine portion.
 replacement and pancreatic adult stem cells, presented results from its Adult Stem Cell Regenerated Islet program at the 44th Annual Meeting of the American Society for Cell Biology in Washington DC, December 4-8, 2004 (www.ascb.org/meetings/am2004/program.html).

AmCyte presented data from its Adult Stem Cell Regenerated Islet Program, which aims to create a transplantable supply of islets for the diabetes patient community. AmCyte's studies show how pancreatic cells can be expanded in culture and treated to resume function and appearance similar to those of isolated Islets of Langerhans islets of Langerhans: see pancreas. .

The data presented at the ASCB meeting show:

--AmCyte is able to expand pancreatic progenitor cells in culture;

--The expanded cells were returned to islet-like function, showed glucagon glucagon (gl`kəgŏn), hormone secreted by the α cells of the islets of Langerhans, specific groups of cells in the pancreas. It tends to counteract the action of insulin, i.e.  and somatostatin Somatostatin

A naturally occurring regulatory peptide that carries out numerous functions in the human body, including the inhibition of growth hormone secretion from the anterior pituitary gland.
, and were able to secrete insulin;

--The resulting progenitor-derived regenerated islets were able to successfully treat diabetic mice, normalizing their blood glucose blood glucose Diabetology The principal sugar produced by the body from food–especially carbohydrates, but also from proteins and fats; glucose is the body's major source of energy, is transported to cells via the circulation and used by cells in the presence .

"Results from this study provide valuable information on the origin of adult human pancreatic progenitor cells and indicate a successful method to differentiate these cells into functional beta cells," said Oliver Foellmer, AmCyte's Director of Business Development. "We are proud to be a leader in demonstrating tangible utility for stem cell approaches at a time when the citizens of California have endorsed stem cell research with Proposition 71. This study not only advances our knowledge of pancreatic stem cell biology but also shows the potential of applying these technologies to treat Type 1 diabetes type 1 diabetes
n.
See diabetes mellitus.
."

AmCyte Inc., located in Santa Monica, California For other uses, see Santa Monica (disambiguation).
Santa Monica is a coastal city in western Los Angeles County, California, USA. Situated on Santa Monica Bay of the Pacific Ocean, it is surrounded by the City of Los Angeles — Pacific Palisades and Brentwood on the north,
, specializes in islet transplantation therapy to treat diabetes. The Adult Stem Cell Regenerated Islet Program along with AmCyte's encapsulation technology will allow AmCyte to move towards its goal of transplanting regenerated islets into patients with diabetes without immune suppression. AmCyte's encapsulation technology protects transplanted islets from immune destruction and allows physicians to transplant islets without immune suppression. The company is developing Regenerated Islets utilizing its proprietary adult stem cell technology to scale up the supply of transplantable islets to meet clinical trial and patient needs.
COPYRIGHT 2004 Business Wire
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Copyright 2004, Gale Group. All rights reserved. Gale Group is a Thomson Corporation Company.

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Publication:Business Wire
Date:Dec 9, 2004
Words:342
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