Altair Nanotechnologies Names Its New Pharmaceutical for Kidney Dialysis Patients Renazorb.Business Editors & Health/Medical Writers RENO, Nev.--(BUSINESS WIRE)--Sept. 10, 2002 Renazorb's(TM) Successful Laboratory Tests For Phosphate Removal Attract Attention of Major Pharmaceutical Companies Altair Nanotechnologies (Nasdaq:ALTI) today announced that it has named its new pharmaceutical for the removal of phosphate ions in kidney dialysis Dialysis, Kidney Definition Dialysis treatment replaces the function of the kidneys, which normally serve as the body's natural filtration system. patients Renazorb(TM). Renazorb(TM) has been developed specifically for the treatment of elevated phosphate levels in patients with end stage renal disease Renal disease Kidney disease. Mentioned in: Glycogen Storage Diseases hypertension High blood pressure Cardiovascular disease An abnormal ↑ systemic arterial pressure, corresponding to a systolic BP of > 160 mm Hg undergoing kidney dialysis. The new pharmaceutical is a lanthanum-based ceramic micro-structured material that effectively binds phosphate and is designed to remove these ions in the gastrointestinal tract gastrointestinal tract n. The part of the digestive system consisting of the stomach, small intestine, and large intestine. Gastrointestinal tract without absorption of the drug into the bloodstream. Altair has already filed patent applications for Renazorb(TM). "When we compared the phosphate binding of Renazorb(TM) with commercially available lanthanum carbonate lanthanum carbonate Fosrenol Pharmacologic class: Phosphate binder Therapeutic class: Renal and genitourinary agent Pregnancy risk category C Actiontetra hydrate hydrate (hī`drāt), chemical compound that contains water. A common hydrate is the familiar blue vitriol, a crystalline form of cupric sulfate. Chemically, it is cupric sulfate pentahydrate, CuSO4·5H2O. in the laboratory using simulated human stomach fluid containing phosphate, Renazorb's(TM) reaction rates for binding the phosphate were approximately twice those displayed by the benchmark material," said Altair President Dr. Rudi E. Moerck."In addition to the rapid removal of phosphate, the amount of Renazorb(TM) required to remove phosphate from the gastrointestinal tract was about 2.5 times less than the benchmark material. This finding is significant as it could reduce the amount of the drug used in dosing and may dramatically increase patient compliance." Moerck went on to note that Renazorb(TM), a highly insoluble drug, showed undetectable amounts of free lanthanum lanthanum (lăn`thənəm) [Gr.,=to lie hidden], metallic chemical element; symbol La; at. no. 57; at. wt. 138.9055; m.p. about 920°C;; b.p. about 3,460°C;; sp. gr. 6.19 at 25°C;; valence +3. in simulated stomach fluid. Altair has executed four confidentiality agreements with major pharmaceutical companies and is currently negotiating a fifth agreement. Three pharmaceutical companies have shown interest in the use of Renazorb(TM) in a filtration device that could be used during kidney dialysis to remove phosphate directly from blood serum Blood serum A component of blood. Mentioned in: Bites and Stings blood serum the residual fluid of blood after clotting has occurred. It is plasma after the fibrinogen has been removed. . Two additional major international pharmaceutical companies have shown a general interest in using Altair's nanomaterials and patented porous nanostructures for drug delivery and pharmaceutical sustained release Sustained-release (SR), extended-release (ER, XR, or XL), time-release or timed-release, controlled-release (CR), or continuous-release (CR or Contin applications. In many cases new drug delivery systems allow pharmaceutical companies to extend patent protection on existing drugs. According to according to prep. 1. As stated or indicated by; on the authority of: according to historians. 2. In keeping with: according to instructions. 3. Moerck, Altair's strategy is to provide laboratory and performance data to a number of pharmaceutical companies and to grant evaluation licenses to those companies that express interest in developing Renazorb(TM) as a drug. The company will also consider exclusive evaluation licenses and exclusive full drug licenses. Altair Nanotechnologies Inc. Nanotechnology is rapidly emerging as a unique industry sector. Altair Nanotechnologies is positioning itself through product innovation within this emerging industry to become a leading supplier of nanomaterials and technology worldwide. Altair owns a proprietary technology for making nanocrystalline materials of unique quality both economically and in large quantities. The company is currently developing special nanomaterials with potential applications in pharmaceuticals, fuel cells, solar cells, advanced energy storage devices, thermal spray coatings, catalysts, cosmetics, paints and environmental remediation. For additional information on Altair's nanoparticle materials, visit www.altairnano.com. Forward-Looking Statements This release may contain forward-looking statements as well as historical information. Forward-looking statements, which are included in accordance with the "safe harbor Safe Harbor 1. A legal provision to reduce or eliminate liability as long as good faith is demonstrated. 2. A form of shark repellent implemented by a target company acquiring a business that is so poorly regulated that the target itself is less attractive. " provisions of the Private Securities Litigation Reform Act The Private Securities Litigation Reform Act of 1995 (PSLRA) implemented several significant substantive changes affecting certain cases brought under the federal securities laws, including changes related to pleading, discovery, liability, class representation and awards fees and of 1995, may involve risks, uncertainties and other factors that may cause the company's actual results and performance in future periods to be materially different from any future results or performance suggested by the forward-looking statements in this release. These risks and uncertainties include, without limitation, the possibilities that the company may be unable to attract additional customers, funded research opportunities, product development opportunities or ventures through its sales and branding campaign, that the company may never earn sufficient revenues to be profitable and that the company's nanoparticle products may not be integrated into any major market groups and products, in addition to other risks identified in the company's most recent Annual Report on Form 10-K Form 10-K A report required by the SEC from exchange-listed companies that provides for annual disclosure of certain financial information. Form 10-K See 10-K. , as filed with the SEC. Such forward-looking statements speak only as of the date of this release. The company expressly disclaims any obligation to update or revise any forward-looking statements found herein to reflect any changes in company expectations or results or any change in events. |
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