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Altachem Pharma Acquires 100% of World Rights to Bionex, a Revolutionary Blood Decontamination Technology.


Business Editors & Health/Medical Writers

BIOWIRE2K

EDMONTON, Alberta--(BW HealthWire)--Sept. 26, 2001

Warren Jackson, President and Chief Executive Officer of Edmonton-based Altachem Pharma Limited, today announced the successful completion of the formal acquisition of 100% of the world rights to develop, manufacture and sell Bionex(TM), a revolutionary compound designed to potentially be used to clean blood products from contamination by a number of viruses, including the HIV/AIDS HIV/AIDS Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome  virus.

While other biotechnology firms are testing technologies that address the issue of contaminated blood products in a particular manner, there are currently no methodologies being marketed by any company designed to inactivate in·ac·ti·vate
v.
1. To render nonfunctional.

2. To make quiescent.



in·acti·va
 bacterial or viral pathogens in cellular or labile labile /la·bile/ (la´bil)
1. gliding; moving from point to point over the surface; unstable; fluctuating.

2. chemically unstable.


la·bile
adj.
1.
 transfusion products. Bionex(TM) is expected to be effective in inactivating these pathogens in contaminated biological fluids such as whole blood. "The Bionex(TM) technology is based on the discovery of novel methods and compositions for treating pathogens that exist, or are transmitted in various human blood transfusion blood transfusion, transfer of blood from one person to another, or from one animal to another of the same species. Transfusions are performed to replace a substantial loss of blood and as supportive treatment in certain diseases and blood disorders.  products and organs," explained Mr. Jackson.

The Canadian Veterinary Medical Association recently indicated that the lack of clinical research is leaving Canada defenseless against the mushrooming number of mysterious diseases that pose a threat to human health. Dr. Alex Livingston, dean of the University of Saskatchewan's Western College of Veterinary Medicine veterinary medicine, diagnosis and treatment of diseases of animals. An early interest in animal diseases is found in ancient Greek writings on medicine. Veterinary medicine began to achieve the stature of a science with the organization of the first school in the , reported that studies indicate that three out of four "emerging" diseases, in humans, come from animal hosts. Among the most devastating dev·as·tate  
tr.v. dev·as·tat·ed, dev·as·tat·ing, dev·as·tates
1. To lay waste; destroy.

2. To overwhelm; confound; stun: was devastated by the rude remark.
 examples are AIDS, variant Creutzfeldt-Jakob Disease Creutzfeldt-Jakob disease: see prion.
Creutzfeldt-Jakob disease
 or CJD

Rare fatal disease of the central nervous system. It destroys brain tissue, making it spongy and causing progressive loss of mental functioning and motor control.
 (vCJD), West Nile virus West Nile virus, microorganism and the infection resulting from it, which typically produces no symptoms or a flulike condition. The virus is a flavivirus and is related to a number of viruses that cause encephalitis. , Hantaviruses, and E.coli. to name only a few.

"The Bionex(TM) technology includes the introduction of one or more of its compounds into a blood bag, either before or after collecting whole blood, allowing the properties of the compound to decontaminate de·con·tam·i·nate  
tr.v. de·con·tam·i·nat·ed, de·con·tam·i·nat·ing, de·con·tam·i·nates
1. To eliminate contamination in.

2.
 the blood," added Mr. Jackson. "As such, if this technology is successfully commercialized, it would be possible to provide whole blood suitable for transfusion without the fear of contamination from HIV HIV (Human Immunodeficiency Virus), either of two closely related retroviruses that invade T-helper lymphocytes and are responsible for AIDS. There are two types of HIV: HIV-1 and HIV-2. HIV-1 is responsible for the vast majority of AIDS in the United States. , hepatitis B Hepatitis B Definition

Hepatitis B is a potentially serious form of liver inflammation due to infection by the hepatitis B virus (HBV). It occurs in both rapidly developing (acute) and long-lasting (chronic) forms, and is one of the most common chronic
 and hepatitis C Hepatitis C Definition

Hepatitis C is a form of liver inflammation that causes primarily a long-lasting (chronic) disease. Acute (newly developed) hepatitis C is rarely observed as the early disease is generally quite mild.
, herpes and other bacteria."

The Bionex(TM) technology also includes methods for treating biological fluids such as plasma, packed red cells packed red cells Transfusion medicine A concentrated unit of RBCs prepared from a unit of whole blood by removing plasma Indications Active bleeding, excess intraoperative blood loss, low 'pre-op' or 'post-op' Hcts, chronic anemias–eg, sickle cell anemia, , bone marrow and sperm, and inactivating any pathogens in the biological fluid - vital in assuring a zero-risk blood product supply.

Mr. Jackson further explained the primary competitive advantages of Bionex(TM). "In addition to being effective against viruses and bacteria, we believe Bionex(TM) to be the first product of its kind that may prove to be safe for human consumption and/or contact. This is of vital importance in the use of blood products for transfusions."

To date, the Bionex(TM) compounds have shown to be viricidal virucidal, viricidal

capable of neutralizing or destroying a virus.
 and bacteriocidal in the initial stages of the experiments. Early experimental research has also indicated that the Bionex(TM) compounds in whole blood do not harm any of the constituents of the blood.

Altachem has acquired the world rights to Bionex(TM) from Bionel, a private biotechnology company in Maryland. These compounds were discovered by Dr. Rene-Guy Bushnel, an internationally-known scientist in the fields of Bio-Acoustics and Biochemistry. Dr. Bushnel is also the inventor of a patented product for surgical gloves and condoms that incorporates a viricide vi·ri·cide or vi·ru·cide
n.
An agent that inhibits or destroys viruses.



viri·cid
 compound between two layers of rubber. These surgical gloves and condoms prevent the inadvertent transmission of an active pathogen through the rubber.

"The Bionex(TM) acquisition is another major milestone for Altachem Pharma and completes our strategy of providing a fully integrated approach to the treatment of HIV/AIDS (Kill the virus with ACP-HIP; stop spread of the virus by blood transfusion with Bionex(TM) and, thirdly, to enhance the quality of life for people with the disease via treatment with Anticort(TM)," explained Mr. Jackson. "The urgent need for this product was further highlighted by recent announcements by the FDA FDA
abbr.
Food and Drug Administration


FDA,
n.pr See Food and Drug Administration.

FDA,
n.pr the abbreviation for the Food and Drug Administration.
 and HPB HPB Health Promotion Board (Singapore)
HPB Hrvatska Poštanska Banka (Croatian Post Bank)
HPB Half Price Books (retail store)
HPB High Ping Bastard
 of blood-donation bans on anyone who has spent considerable time in Europe. The ban is expected to have a large impact on the national blood donor pool according to the FDA. USA TODAY reported, in a recent article, that the impact could be far greater regionally. In the New York Metro For the region, see .

Metro New York is a free daily newspaper in New York City started in 2004. Its main competition is AM New York, with which it practices many of the same distribution and marketing strategies.
 area, for example, where 25% of blood used is imported from Europe, the blood supply is expected to drop 35%.The successful commercialization of this technology is of significant importance to the intended recipients of blood products as well as the blood treatment industry world-wide," said Mr. Jackson.

Altachem Pharma Ltd. is a publicly traded (CDNX CDNX

See Canadian Venture Exchange (CDNX).
:AAF AAF
abbr.
Army Air Forces
), Alberta-based pharmaceutical company committed to developing new and improved pharmaceutical products to globally enhance the quality of life. Altachem invests in, develops, manufactures and distributes pharmaceutical products in Canada and internationally. The Company is certified compliant with internationally recognized quality systems standards, ISO (1) See ISO speed.

(2) (International Organization for Standardization, Geneva, Switzerland, www.iso.ch) An organization that sets international standards, founded in 1946. The U.S. member body is ANSI.
 9002:1994, ISO 13488 and EN 46002.

For additional information, contact:
Roger Andrews,                         Don Bain, Vice-President
Manager-Investor Relations             McManus Elliott Communications
Altachem Pharma Ltd.                   Tel. (416) 979-8300 (Ext. 237)
Tel. (780) 486-8331(Ext. 331)          Fax. (416) 979-8638
Toll-free (877) 502-5939(Ext. 331)     E-mail:  don@mcmanuselliott.com
Fax (780) 448-1436
E-mail: roger@altachempharma.com
Web site: www.altachempharma.com


Certain information contained in this press release may be forward-looking and is subject to unknown risks and uncertainties. Although the Company believes that the expectations reflected in such forward-looking statements are reasonable, it can give no assurance that such expectations will prove correct. This is neither an offer to buy or sell a security. For informational purposes only, from sources deemed to be reliable.

"CDNX has neither approved nor disapproved of the information contained herein."

        BACKGROUND SHEET TO ALTACHEM PHARMA/BIONEX NEWS RELEASE

The  Buoyant Blood Treatment & Blood Transfusion Market

    --  The market for blood products is over $ 10 billion and growing
        and with more than 90 million units of blood donated
        world-wide every year, the need for methods to improve the
        safety of blood products is truly significant. (5)

    --  "Any new technology to make the blood supply safer has been
        very well received by the public and has been adopted quickly
        by blood banks," says Richard Davey, Chief Medical Officer for
        American Red Cross. (3)

    --  Recent announcements by FDA and HPB banning blood donations by
        anyone who has spent considerable time in Europe is expected
        to have a large impact on the USA national donor pool
        according to the FDA. The impact could be far greater
        regionally. In New York Metro area, where 25% of blood used is
        imported from Europe, the blood supply is expected to drop
        35%.(4)

The Importance of Zero-Risk Blood Supplies and Products

    --  Number of people worldwide currently living with HIV/AIDS (at
        end 2000): 36.1 million(2)

    --  Number of people worldwide newly infected with HIV virus (at
        end 2000): 5.3 million(2)

    --  Number of people worldwide infected with Hepatitis B virus (at
        end 2000): 2.0 billion (7)

    --  Number of people worldwide with chronic (lifelong) Hepatitis B
        (at end 2000): 350 million (7)

    --  Number of people worldwide infected with Hepatitis C virus (at
        end 2000): 170 million (7)

Consumer Demands - Which Bionex(TM) May Possibly Meet

    --  Contaminant-free biological fluids such as whole blood or
        blood products intended for transfusion. Technology that may
        be proven to provide zero-risk blood transfusion products.

    --  The need to replace a Donor-Screening System that at best,
        only slightly increases the chance of blood safety.

    --  The Canadian Veterinary Medical Association indicated, in a
        recent article, that lack of clinical research is leaving
        Canada defenseless against the mushrooming number of
        mysterious diseases that pose a threat to human health. Dr.
        Alex Livingston, dean of the University of Saskatchewan's
        Western College of Veterinary Medicine, reported that "Studies
        indicate that three out of four "emerging" diseases, in
        humans, come from animal hosts. Among the most devastating
        examples are AIDS, variant Creutzfeldt-Jakob Disease (vCJD),
        West Nile virus, Hantaviruses, and E.coli. to name only a
        few.(6)

    Sources: (1) Bionel; (2) United Nations Joint Initiative on
    Aids(UNAIDS); (3) American Red Cross; (4) USA TODAY; (5) Cerus
    Corp; (6) Edmonton Journal (23-06-2001 A5); (7) World Heath
    Organization (WHO)
COPYRIGHT 2001 Business Wire
No portion of this article can be reproduced without the express written permission from the copyright holder.
Copyright 2001, Gale Group. All rights reserved. Gale Group is a Thomson Corporation Company.

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