AlphaRx Introduces Phystrol E and LipoBloc with Solubilized Phytosterols for Lowering Blood Cholesterol.Business Editors and Health/Medical Writers BIOWIRE2K RICHMOND HILL, Ontario--(BW HealthWire)--Feb. 1, 2001 AlphaRx Inc. (OTCBB OTCBB See OTC Bulletin Board (OTCBB). :AHRX) announced today the introduction of Phystrol E(TM) and LipoBloc(TM), two unique dietary supplements that feature fully solubilized plant sterols sterols (ster´ôlz), n.pl steroids having one or more hydroxyl groups and no carbonyl or carboxyl groups (e.g., cholesterol). or phytosterols for the management of high blood cholesterol. Phytosterols are naturally occurring plant extracts, which have a molecular structure virtually identical to that of cholesterol but are insoluble in water and oil, thus making them extremely low in bioavailability. In one clinical trial, 300mg phytosterols administered in lecithin lecithin Any of a class of phospholipids (also called phosphatidyl cholines) important in cell structure and metabolism. They are composed of phosphate, choline, glycerol (as the ester), and two fatty acids. Various fatty acids pairs distinguish the various lecithins. micelles reduced cholesterol absorption as much as 34.4% as compared to a 11.5% reduction in three times the quantity of phytosterols in powder form alone. The solubility of phytosterols was greatly increased by lecithin, with about 29% phytosterols solubilized. There is a direct correlation between the solubility of phytosterols and their effectiveness in cholesterol reduction. Phytosterols are currently being incorporated in margarines to promote healthy cholesterol levels. However, margarine products themselves contain significant amounts of fat and calories. AlphaRx's clinically proven delivery system makes Phystrol E(TM) & LipoBloc(TM) significantly more soluble and bioavailable than other phytosterol products, enhancing their attachment to cholesterol absorption sites in the small intestine and further reducing serum total and LDL LDL - ["LDL: A Logic-Based Data-Language", S. Tsur et al, Proc VLDB 1986, Kyoto Japan, Aug 1986, pp.33-41]. levels as a result. AlphaRx will offer Phystrol E(TM) in Canada and LipoBloc(TM) internationally. Research results in the area of plant (phyto) sterols have been so encouraging, that they have recently prompted the FDA FDA abbr. Food and Drug Administration FDA, n.pr See Food and Drug Administration. FDA, n.pr the abbreviation for the Food and Drug Administration. (T00-40 September 5, 2000) to authorize the use of labeling health claims on foods and dietary supplements containing these substances which endorse the role of plant sterol Sterol Any of a group of naturally occurring or synthetic organic compounds with a steroid ring structure, having a hydroxyl (—OH) group, usually attached to carbon-3. or plant stanol esters in reducing the risk of coronary heart disease coronary heart disease: see coronary artery disease. coronary heart disease or ischemic heart disease Progressive reduction of blood supply to the heart muscle due to narrowing or blocking of a coronary artery (see atherosclerosis). (CHD CHD coronary heart disease. ChD abbr. Latin Chirurgiae Doctor (Doctor of Surgery) CHD, n.pr See disease, coronary heart. CHD canine hip dysplasia. ) by lowering blood cholesterol levels. About AlphaRx AlphaRx is engaged in the development of novel formulations of drugs that are insoluble or poorly soluble in water. For additional information, please visit our web-site at www.AlphaRx.com FORWARD LOOKING STATEMENTS: This release contains forward-looking statements within the meaning and pursuant to the Safe Harbor provisions of the Securities Litigation Reform Act of 1995 and involve risks and uncertainties that may individually or mutually impact the matters herein described, including but not limited to product development and acceptance, manufacturing, competition, regulatory and/or other factors, which are outside the control of the Company. |
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