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Allergan and Kyorin Pharmaceutical Co., Ltd. Sign Exclusive Licensing Agreement to Develop and Market ALPHAGAN-R-/ ALPHAGAN-R- P in Japan.


Business Editors/Health/Medical Writers

IRVINE, Calif.--(BUSINESS WIRE)--May 26, 2004

Allergan, Inc. (NYSE NYSE

See: New York Stock Exchange
:AGN AGN Again (Amateur Radio)
AGN Active Galactic Nucleus
AGN Acute Glomerulonephritis
AGN Accountants Global Network
AGN Air Gabon (ICAO code) 
) today announced that it has entered into an exclusive licensing agreement with Kyorin Pharmaceutical, Co., Ltd. (Kyorin) in Japan to develop and market the ALPHAGAN(R)/ ALPHAGAN(R) P Franchise (Brimonidine Tartrate tartrate /tar·trate/ (tahr´trat) a salt of tartaric acid.

tar·trate
n.
A salt or ester of tartaric acid.



tartrate

a salt of tartaric acid.
 solution 0.2 percent and Brimonidine Tartrate Purite solution 0.15 percent) within the ophthalmic specialty area. The ALPHAGAN(R) Franchise represents the third largest selling glaucoma glaucoma (glôkō`mə), ocular disorder characterized by pressure within the eyeball caused by an excessive amount of aqueous humor (the fluid substance filling the eyeball).  franchise in the world as measured by 2003 revenue, according to according to
prep.
1. As stated or indicated by; on the authority of: according to historians.

2. In keeping with: according to instructions.

3.
 IMS Health IMS Health (NYSE: RX) is an international consulting and data services company that supplies the pharmaceutical industry with sales data and consulting services. IMS Health was founded in 1954 by Bill Frohlich and David Dubow.  Inc. In 2003, global sales for the ALPHAGAN(R) Franchise were $287 million.

Under the terms of the licensing agreement, Kyorin will be responsible for the development and commercialization of ALPHAGAN(R)/ ALPHAGAN(R) P in Japan and will incur associated costs. Kyorin will provide Allergan with an up-front payment, as well as development and commercialization milestone payments. In addition, Kyorin will pay Allergan a royalty based on product sales. Allergan and Kyorin will work collaboratively on overall product strategy and management.

Brimonidine tartrate, the active ingredient An active ingredient, also active pharmaceutical ingredient (or API), is the substance in a drug that is pharmaceutically active. Some medications may contain more than one active ingredient.  in ALPHAGAN(R)/ALPHAGAN(R) P is a relatively selective alpha-2 adrenergic agonist An adrenergic is a drug, or other substance, which has effects similar to, or the same as, epinephrine (adrenaline). Alternatively, it may refer to something which is susceptible to epinephrine, or similar substances, such as a biological receptor (specifically, the adrenergic  for ophthalmic use. It is believed to have a dual mechanism of action by reducing aqueous humor aqueous humor
n.
The clear, watery fluid circulating in the chamber of the eye between the cornea and the lens.


Aqueous humor 
 production and increasing uveoscleral outflow. Due to their favorable safety and efficacy profiles, the ALPHAGAN(R)/ ALPHAGAN(R) P Franchise products have become a preferred choice for the treatment of elevated intraocular pressure intraocular pressure
n.
The pressure of the intraocular fluid within the eye.


intraocular pressure (in´tr
 in patients with glaucoma and ocular hypertension Ocular hypertension (OHT) is intraocular pressure higher than normal in the absence of optic nerve damage or visual field loss.[1][2]

Current consensus in ophthalmology defines normal introcular pressure (IOP) as that between 10 mmHg and 21 mmHg.
 in numerous markets around the world.

"We are pleased to be entering into this licensing agreement with Kyorin, which is our third such agreement with Kyorin," said David Pyott, Allergan's Chairman of the Board, President and Chief Executive Officer. "Kyorin has proven to be a highly committed partner that is strongly driven to produce a successful outcome. Given the strength of the glaucoma market in Japan, we are confident that Kyorin will maximize the potential of this exceptional technology."

The glaucoma market in Japan is currently estimated to be over $500 million annually. The market has experienced strong growth over the last few years and, given Japan's population demographics, it is expected that the total number of patients will continue to increase.

About Allergan, Inc.

Allergan, Inc., with headquarters in Irvine, California, is a technology-driven, global health care company providing eye care and specialty pharmaceutical products worldwide. Allergan develops and commercializes products in the eye care, neuromodulator and skin care markets that deliver value to our customers, satisfy unmet medical needs, and improve patients' lives.

About Kyorin Pharmaceutical, Co., Ltd.

Kyorin Pharmaceutical Co., Ltd., located in Tokyo, Japan, is a fully-integrated, research-oriented pharmaceutical company developing new compounds with a focus in the main therapeutic areas independently, and in collaboration with sophisticated outside research institutes.

Forward-looking Statements

This press release contains "forward-looking statements", including the statements by Mr. Pyott, statements regarding research and development outcomes, efficacy, safety and side-effect profiles, and market and product potential. These statements are based on current expectations of future events. Any other statements in this press release that refer to Allergan's expected, estimated or anticipated future results are also forward-looking statements. All forward-looking statements in this press release reflect Allergan's current analysis of existing trends and information and represent Allergan's judgment only as of the date of this press release. Actual results may differ materially from current expectations based on a number of factors affecting Allergan's businesses, including among other things, changing competitive market and regulatory conditions; the timing and uncertainty of the results of both the research and development and regulatory processes; domestic and foreign health care and cost containment cost containment,
n the features of a dental benefits program or of the administration of the program designed to reduce or eliminate certain charges to the plan.
 reforms; technological advances and patents obtained by competitors; the performance, including the approval, introduction and consumer and physician acceptance of new products and the continuing acceptance of currently marketed products; the effectiveness of advertising and other promotional campaigns; the timely and successful implementation of strategic initiatives; the results of any pending litigations, investigations or claims; the uncertainty associated with the identification of and successful consummation and execution of external corporate development initiatives and strategic partnering transactions; and Allergan's ability to obtain and successfully maintain a sufficient supply of products to meet market demand in a timely manner. In addition, matters generally affecting the economy, such as changes in interest and currency exchange rates; international relations; and the state of the economy worldwide, can affect Allergan's results. Therefore, the reader is cautioned not to rely on these forward-looking statements. Allergan expressly disclaims any intent or obligation to update these forward-looking statements.

Additional information concerning these and other risk factors can be found in press releases issued by Allergan as well as Allergan's public periodic filings with the Securities and Exchange Commission, including the discussion under the heading "Certain Factors and Trends Affecting Allergan and its Businesses" in Allergan's 2003 Form 10-K Form 10-K

A report required by the SEC from exchange-listed companies that provides for annual disclosure of certain financial information.


Form 10-K

See 10-K.
 and Allergan's Form 10-Q Form 10-Q

See 10-Q.
 for the quarter ended March 26, 2004. Copies of Allergan's press releases, and additional information about Allergan is available at www.allergan.com or you can contact the Allergan Investor Relations Investor relations

The process by which the corporation communicates with its investors.
 Department by calling 714-246-4636.
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Publication:Business Wire
Geographic Code:1USA
Date:May 26, 2004
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