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Allergan Launches PREVAGE-TM- Antioxidant Cream, the First and Only Clinically Tested Antioxidant That Corrects and Protects the Skin.


IRVINE, Calif. -- Allergan, Inc. (NYSE NYSE

See: New York Stock Exchange
:AGN AGN Again (Amateur Radio)
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) today announced the launch of PREVAGE(TM) antioxidant antioxidant, substance that prevents or slows the breakdown of another substance by oxygen. Synthetic and natural antioxidants are used to slow the deterioration of gasoline and rubber, and such antioxidants as vitamin C (ascorbic acid), butylated hydroxytoluene  cream, the first and only clinically tested antioxidant that not only reduces the appearance of fine lines History
Fine Lines is a new Japanese rock band that consist two members from band called Husking Bee. Their dual emotionally charged vocalists, and impressive musicianship of the members: Tetsuya Kudo on bass, Kazuya Hirabayashi on guitar and vocals, George Kurosawa on guitar
 and wrinkles, but also provides protection against environmental factors including sun damage, air pollution and cigarette smoke.(1)

Representing the next generation of antioxidants Antioxidants
Substances that reduce the damage of the highly reactive free radicals that are the byproducts of the cells.

Mentioned in: Aging, Nutritional Supplements

antioxidants,
n.
, PREVAGE(TM) antioxidant cream is a novel cosmeceutical cos·me·ceu·ti·cal
n.
A cosmetic that has or is purported to have medicinal properties.
 containing 1 percent idebenone - a revolutionary, potent and effective new antioxidant.

"We had sun block in the seventies and glycolic acids in the eighties, and now we have PREVAGE(TM) antioxidant cream, the first advance we have seen in decades that is backed by scientific studies," said Jeanine B. Downie, M.D., Director of Image Dermatology, Montclair, New Jersey. "PREVAGE(TM) antioxidant cream is a potent antioxidant that is clinically proven to not only protect the skin against sun damage and the environment, but also to correct fine lines and wrinkles."

Proven Scientific Evidence

Data that compare leading antioxidants show that idebenone is the most effective topical antioxidant product available.(1) A six-week clinical study evaluated the use of PREVAGE(TM) antioxidant cream containing a 1 percent concentration of idebenone in 21 women between the ages of 18 and 65 with moderate photoaging pho·to·ag·ing
n.
1. The process by which skin is changed or damaged as a result of exposure to ultraviolet radiation in sunlight and other sources.

2.
 (dry facial skin and fine lines/wrinkles). The women in the study applied PREVAGE(TM) antioxidant cream twice a day to the facial area for six weeks. Study results included:

--29 percent reduction in the appearance of fine lines and wrinkles;

--26 percent reduction in skin roughness or dryness;

--37 percent increase in skin hydration hydration /hy·dra·tion/ (hi-dra´shun) the absorption of or combination with water.

hy·dra·tion
n.
1. The addition of water to a chemical molecule without hydrolysis.

2.
; and,

--33 percent overall global improvement in the appearance of skin.(2)

"While other creams just sit on the skin's surface, the unique formulation of PREVAGE(TM) antioxidant cream allows it to penetrate the skin at the cellular level to help prevent free radicals from breaking down the collagen and elastin elastin /elas·tin/ (e-las´tin) a yellow scleroprotein, the essential constituent of elastic connective tissue; it is brittle when dry, but when moist is flexible and elastic.

e·las·tin
n.
 in the skin," added Dr. Downie.

"PREVAGE(TM) antioxidant cream is the newest addition to our dermatology franchise," said Bob Rhatigan, Vice President, Allergan's U.S. Dermatology business unit. "With a rich heritage in skincare, we are excited to continue providing dermatologists and plastic surgeons with products supported by science and proven results."

PREVAGE(TM) antioxidant cream is available exclusively through dermatologists' and plastic surgeons' offices. To locate an office or for more information, please visit www.prevage.com.

About Idebenone

When compared to other commonly known topical antioxidants available in skincare products, idebenone is the most potent and effective antioxidant compound. Idebenone has been found to be effective in protecting the skin against key environmental stressors known to cause fine lines and wrinkles including: ultraviolet radiation, ozone, air pollution and cigarette smoke. It also was ranked the most effective compound tested in a series of biochemical and cell-biological methods used to determine the effectiveness of antioxidant compounds at preventing biological damage as a result of oxidative stress oxidative stress,
n an imbalance of the prooxidant antioxidant ratio in which too few antioxidants are produced or ingested or too many oxidizing agents are produced.
.(1)

A close relative of the compound Co-Enzyme Q10, idebenone has far greater skin penetration potential and a much higher oxidative stress protection capacity.(1) Its lower molecular weight allows for greater skin penetration and extended shelf life stability.

About Allergan, Inc.

Allergan, Inc., with headquarters in Irvine, California Irvine is an incorporated city in Orange County, California, United States. It is a planned city, mainly developed by the Irvine Company since the 1960s. Formally incorporated on December 28 1971, the 69.7 square mile (180.5 km²) city has a population of 202,079 (as of 2007). , is a technology-driven, global health care company providing specialty pharmaceutical products worldwide. Allergan develops and commercializes products in the eye care, neuromodulator, skin care and other specialty markets that deliver value to its customers, satisfy unmet medical needs, and improve patients' lives.

Forward-Looking Statements

This press release contains "forward-looking statements," including the statements by Dr. Downie and other statements regarding the effectiveness of PREVAGE(TM) antioxidant cream. These statements are based on current expectations of future events. If underlying assumptions prove inaccurate or unknown risks or uncertainties materialize, actual results could vary materially from Allergan's expectations and projections. Risks and uncertainties include, among other things, general industry and pharmaceutical market conditions; general domestic and international economic conditions, such as interest rate and currency exchange rate fluctuations; technological advances and patents attained by competitors; challenges inherent in the research and development and regulatory processes; challenges related to new product marketing, such as the unpredictability of market acceptance for new pharmaceutical and biologic products and/or the acceptance of new indications for such products; potential difficulties in manufacturing a new product formulation; domestic and foreign health care reforms; trends toward managed care and health care cost containment cost containment,
n the features of a dental benefits program or of the administration of the program designed to reduce or eliminate certain charges to the plan.
; and governmental laws and regulations affecting domestic and foreign operations. Additional information concerning these and other risk factors can be found in press releases issued by Allergan, as well as Allergan's public periodic filings with the Securities and Exchange Commission, including the discussion under the heading "Certain Factors and Trends Affecting Allergan and its Businesses" in Allergan's 2003 Form 10-K Form 10-K

A report required by the SEC from exchange-listed companies that provides for annual disclosure of certain financial information.


Form 10-K

See 10-K.
 and Allergan's Form 10-Q Form 10-Q

See 10-Q.
 for the quarter ended March 26, 2004. Copies of Allergan's press releases and additional information about Allergan is available on the World Wide Web at www.allergan.com or you can contact the Allergan Investor Relations Investor relations

The process by which the corporation communicates with its investors.
 Department by calling 1-714-246-4636.
(1) 2004 AAD Poster Exhibit: Antioxidants Compared in a New Protocol
    to Measure Protective Capacity Against Oxidative Stress - Part II;
    DiNardo, J., Lewis, J., Neudecker, B., Dimitar, B., Wieland, E.,
    Maibach, H.

(2) Six Week Clinical Evaluation of PREVAGE(TM) for the Treatment of
    Photoaging; DiNardo, J.
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Publication:Business Wire
Geographic Code:1USA
Date:Jan 4, 2005
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