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Agilent Technologies and BioTrove Sign Collaborative Marketing Agreement for Ultra-High-Throughput Mass Spectrometry Solution.


Collaboration to Improve Drug-Discovery Efficiency through Automated Sample Preparation, Analysis with Unsurpassed Throughput

SANTA CLARA Santa Clara, city, Cuba
Santa Clara (sän`tä klä`rä), city (1994 est. pop. 217,000), capital of Villa Clara prov., central Cuba.
, Calif. & WOBURN, Mass. -- Agilent Technologies This article needs sources or references that appear in reliable, third-party publications. Alone, primary sources and sources affiliated with the subject of this article are not sufficient for an accurate encyclopedia article.  Inc. (NYSE NYSE

See: New York Stock Exchange
: A) and BioTrove Inc. today announced they have signed an agreement to co-market the Agilent 6410 Triple Quadrupole A quadrupole is one of a sequence of configurations of electric charge or gravitational mass that can exist in ideal form, but it is usually just part of a multipole expansion of a more complex structure reflecting various orders of complexity.  Mass Spectrometer with BioTrove's RapidFire high-throughput sample preparation systems. The two systems together provide an integrated solution for ultra-high-throughput preparation and analysis of in vitro in vitro /in vi·tro/ (in ve´tro) [L.] within a glass; observable in a test tube; in an artificial environment.

in vi·tro
adj.
In an artificial environment outside a living organism.
 biological assays in pharmaceutical drug research.

"This relationship enables clients to integrate the fastest sample-preparation system on the market with the strength of leading-edge analytical mass spectrometry mass spectrometry
 or mass spectroscopy

Analytic technique by which chemical substances are identified by sorting gaseous ions by mass using electric and magnetic fields.
," said Guenter Nill, Agilent general manager, pharmaceutical and biotech market. "It significantly benefits pharmaceutical companies that want to spend less time and money discovering new leads and developing more effective medicines."

Using innovative microfluidic technology for sample preparation and analysis faster than eight seconds per sample, RapidFire Mass Spectrometry (RF-MS) eliminates bottlenecks created by traditional mass spectrometry throughput. It has been used by 10 of the top 15 pharmaceutical companies as an established drug-discovery tool for more than four years. RF-MS is routinely used in applications including the high-throughput screening of previously intractable drug targets, cytochrome cytochrome (sī`təkrōm'), protein containing heme (see coenzyme) that participates in the phase of biochemical respiration called oxidative phosphorylation.  P450 inhibition and other pre-clinical ADME ADME Absorption, Distribution, Metabolism, and Excretion
ADME Association of Destination Management Executives
ADME Active Duty Medical Extension
 assays, as well as in directed evolution studies.

The Agilent 6410 Triple Quadrupole LC/MS LC/MS Liquid Chromatography/Mass Spectrometry  establishes a new standard for value in a triple quadrupole mass spectrometer, delivering outstanding sensitivity and great ease of use along with traditional Agilent reliability. Femtogram-level sensitivity and rugged, reliable performance make this the instrument of choice for drug discovery and development.

"The Agilent-BioTrove collaboration provides an improved, integrated high-throughput screening solution, enabling biopharmaceutical companies to better use their talent, time and targets," said Al Luderer, Ph.D., president and CEO (1) (Chief Executive Officer) The highest individual in command of an organization. Typically the president of the company, the CEO reports to the Chairman of the Board. , BioTrove. "BioTrove's expertise in sample preparation for high-throughput screening and early ADME is a natural complement to Agilent's strength in analytical mass spectrometry. Together, we are enabling walk-away analysis of lead compounds against valuable targets that would be otherwise impossible to screen, helping biopharma clients meet the challenge of accelerating drug discovery research."

The combined solutions can be seen at the following events:

* Chemical and Pharmaceutical Structure Analysis Conference in Langhorne, Pa., on Oct. 22-25; and

* American Association of Pharmaceutical Scientists Conference in San Diego on Nov. 11-15.

About BioTrove, Inc.

BioTrove, Inc. offers two innovative technology platforms: RapidFire[TM], which enables the acceleration of drug discovery and pipeline decisions, and OpenArray[TM], which advances genomic research in a wide range of life science fields, including agriculture, disease research, bio-defense, and public health. With more than half of the world's ten largest pharmaceutical companies as clients, and partnerships with prestigious research and public health centers around the world, BioTrove's products and services ensure that an industry committed to accuracy and speed can meet business goals.

RapidFire[TM] Mass Spectrometry (RFMS RFMS Recipient Financial Management System (Pell Grants)
RFMS Regional Financial Management System
RFMS Reading-Fleming Middle School
RFMS Rotorcraft Flight Manual Supplement (US FAA) 
) uses an innovative microfluidic technology to facilitate analysis at faster than 10 seconds per sample, eliminating the bottleneck created by traditional mass spectrometry throughput. RFMS is routinely used in many applications including the high-throughput screening of previously intractable drug targets, cytochrome P450 inhibition and other ADME assays and directed evolution studies.

The OpenArray[TM] Platform enables genomics researchers to generate SNP SNP Scottish National Party

Noun 1. SNP - (genetics) genetic variation in a DNA sequence that occurs when a single nucleotide in a genome is altered; SNPs are usually considered to be point mutations that have been evolutionarily
 and real time qPCR data in the hundreds of thousands of data points per day, significantly increasing the number of samples analyzed while significantly decreasing the time and cost required. The flexible format and nanoliter scale of the OpenArray[TM] system allows for easy adjustment of sample and assay numbers, achieving economical, high-throughput genomics.

For more information, please visit www.biotrove.com.

About Agilent Technologies

Agilent Technologies Inc. (NYSE: A) is the world's premier measurement company and a technology leader in communications, electronics, life sciences and chemical analysis. The company's 19,000 employees serve customers in more than 110 countries. Agilent had net revenue of $5.0 billion in fiscal 2006. Information about Agilent is available on the Web at www.agilent.com.
COPYRIGHT 2007 Business Wire
No portion of this article can be reproduced without the express written permission from the copyright holder.
Copyright 2007, Gale Group. All rights reserved.

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Publication:Business Wire
Date:Oct 17, 2007
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