Agilent Technologies Releases Probe Sequence, Annotation Information for All Its Commercial Gene Expression Microarrays.
PALO ALTO Palo Alto, city, California
Palo Alto (păl`ō ăl`tō), city (1990 pop. 55,900), Santa Clara co., W Calif.; inc. 1894. Although primarily residential, Palo Alto has aerospace, electronics, and advanced research industries. , Calif. -- Agilent Technologies This article needs sources or references that appear in reliable, third-party publications. Alone, primary sources and sources affiliated with the subject of this article are not sufficient for an accurate encyclopedia article. Inc. (NYSE NYSE
See: New York Stock Exchange :A) today announced that it has for the first time released the chip design, probe sequence and annotation information for all of its microarrays. The release of this information is expected to improve cross-laboratory experimental research and cross-platform data comparison.
"Full release of the probe sequences is an admirable and responsible position for Agilent to take," said Catherine Ball, president of the Microarray Gene Expression Data (MGED MGED Microarray Gene Expression Data
MGED Multidevice Graphics Editor ) Society and director of the Stanford Microarray Database. "Rigorous science requires that others be able to easily interpret and verify or contradict one's work. With this sequence information, the research community will be better equipped to interpret data generated with Agilent arrays and to determine confidence in these data in future years, when genomic sequences may have been updated. In that sense, release of these sequences makes the results of experiments using Agilent arrays far more valuable."
This announcement is being made in conjunction with the extensive release of microarray experimental data into the public domain by the National Toxicology Program National Toxicology Program Environment A program that conducts toxicologic tests on substances frequently found at the EPA's National Priorities List sites, which have the greatest potential for human exposure . Icoria Inc., under its contract with the National Institute of Environmental Health Sciences The National Institute of Environmental Health Sciences (NIEHS) is one of 27 Institutes and Centers of the National Institutes of Health (NIH),which is a component of the Department of Health and Human Services (DHHS). The Director of the NIEHS is Dr. David A. Schwartz. (NIEHS NIEHS National Institute of Environmental Health Sciences (NIH, DHHS) ), has been using Agilent microarrays to perform thousands of experiments to profile chemical effects on biological systems, thereby creating a vast resource of gene expression responses to chemical toxicants. The data will eventually be made available through the NIEHS National Center of Toxicogenomics' Chemical Effects on Biological Systems (CEBS CEBS Committee of European Banking Supervisors
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CEBS Charles Edward Brooke School (UK) ) database, currently under development.
"The NIEHS National Center for Toxicogenomics is very pleased that Agilent has released the probe sequences for its gene expression microarrays to the public domain," said Michael Waters, Ph.D., assistant director for database development of the NCT NCT National Childbirth Trust
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NCT Nicotine Replacement Therapy . "The availability of these sequences will be of great benefit to the microarray bioinformatics community and to databases such as the NCT's CEBS as we seek to make high-quality toxicogenomics data sets publicly available."
The microarray design and probe sequence information is now available on Agilent's eArray web portal at earray.chem.agilent.com. On the same site, customers can examine the content of Agilent-manufactured commercial microarrays and design their own custom microarrays. Agilent-manufactured microarrays are based on the industry-standard 1" x 3" slide format, making them readily and easily accessible to any researchers who want to achieve a high degree of sensitivity and precision in their experiments.
About Agilent Integrated Biology Solutions
Agilent Technologies is a leading supplier of life science research systems that enable scientists to understand complex biological processes, determine disease mechanisms and speed drug discovery. Engineered for sensitivity, reproducibility and workflow productivity, Agilent's integrated biology solutions include instrumentation, microfluidics, software, microarrays, consumables and services for genomics, proteomics and metabolomics applications.
About Agilent Technologies
Agilent Technologies Inc. (NYSE:A) is a global technology leader in communications, electronics, life sciences and chemical analysis. The company's 28,000 employees serve customers in more than 110 countries. Agilent had net revenue of $7.2 billion in fiscal year 2004. Information about Agilent is available on the Web at www.agilent.com.
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