Aggregate Exposure Assessment for Pesticides: Longitudinal Case Studies.The U.S. Environmental Protection Agency Environmental Protection Agency (EPA), independent agency of the U.S. government, with headquarters in Washington, D.C. It was established in 1970 to reduce and control air and water pollution, noise pollution, and radiation and to ensure the safe handling and (EPA EPA eicosapentaenoic acid. EPA abbr. eicosapentaenoic acid EPA, n.pr See acid, eicosapentaenoic. EPA, n. ) will support longitudinal case studies designed to assess aggregate, nonoccupational exposures to pesticides in defined populations aimed at addressing important public health issues. These issues may concern the toxicity of a particular chemical or class of chemicals and/or relate to a health end point and its potential link to pesticide exposures. Specifically, there is a need for information on aggregate human exposures to commercial pesticide chemicals such as pyrethroid py·re·throid n. Any of several synthetic compounds similar to pyrethrin, used as an insecticide. insecticides, triazine tri·a·zine n. 1. Any of three isomeric compounds, C3H3N3, each having three carbon and three nitrogen atoms in a six-membered ring. 2. A compound derived from one of these isomers. herbicides, and residential use pesticides. The EPA is seeking grant proposals that describe studies for assessing pesticide exposure that incorporate estimates of temporal and interindividual variability. Successful proposals will be those that effectively include and address as many of the following as possible in longitudinal studies longitudinal studies, n.pl the epidemiologic studies that record data from a respresentative sample at repeated intervals over an extended span of time rather than at a single or limited number over a short period. : 1) the identification of study hypotheses that are supported by rationales for the selection of the population of concern (characteristics and numbers) and the target pesticides in relation to the environmental and public health issues associated with their use; 2) the development of approaches for assessing pesticide exposures via multiple pathways and routes (e.g., inhalation, dietary and nondietary ingestion ingestion /in·ges·tion/ (-chun) the taking of food, drugs, etc., into the body by mouth. in·ges·tion n. 1. The act of taking food and drink into the body by the mouth. 2. , and dermal dermal /der·mal/ (der´mal) pertaining to the dermis or to the skin. der·mal or der·mic adj. Of or relating to the skin or dermis. contact), emphasizing temporal variation in exposure and exposure-related factors; 3) the development of improved methods for assessing exposures to specific classes of pesticides, including methods to determine the temporal nature of various sources and the resulting impact on exposure; 4) the evaluation of exposures to pesticides resulting from various sources (e.g., agricultural application to food crops, residential lawn treatment, indoor residential uses, pet uses) and apportionment The process by which legislative seats are distributed among units entitled to representation; determination of the number of representatives that a state, county, or other subdivision may send to a legislative body. The U.S. of the exposures and doses; 5) the development of methods to account for short-term, intermittent exposures to pesticides and evaluation of the importance of aggregate exposures under such conditions; and 6) the development of assessments of pesticide exposure that include evaluations of the uncertainty and variability associated with the exposure estimates. Up to $6 million is expected to be available in FY 2001 for awards in this program area. The projected award range is $250,000-350,000 per year. This amount includes direct and indirect costs Indirect costs are costs that are not directly accountable to a particular function or product; these are fixed costs. Indirect costs include taxes, administration, personnel and security costs. See also
Instructions for applying for a Science To Achieve Results (STAR) grant are found on the National Center for Environmental Research Web site at http://www.epa.gov/ncerqa/. Standard instructions for submitting a STAR application and the necessary application forms are available on this Web site. Applicants should note that for this solicitation only, the research plan may be as long as 25 pages, rather than the 15 pages stated in the standard instructions. The deadline for receipt of applications is 7 March 2001. Contact: Chris Saint, 202-564-6909, e-mail: saint.chris@epa.gov. E-mail inquiries are preferred. Reference: 2001-STAR-G1 |
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