Agencourt Scientists Participate in the Genome Sequencing of the Brown Norway Rat; Agencourt in Collaboration with Other Major Sequencing Centers Publishes Paper in Nature.
Business Editors/Health/Medical Writers
BEVERLY, Mass.--(BUSINESS WIRE)--March 31, 2004
Agencourt Bioscience Corporation, a provider of genomic services and nucleic acid nucleic acid, any of a group of organic substances found in the chromosomes of living cells and viruses that play a central role in the storage and replication of hereditary information and in the expression of this information through protein synthesis. purification products to the life sciences industry, today announced the publication of the rat genome sequence in the April 1 issue of Nature. Agencourt scientists contributed to the whole genome sequencing effort on the medically important model organism, the brown Norway rat. This sequence represents a high-quality draft covering over 90 percent of the genome and provides a comprehensive analysis of genes and proteins and their relationship to human disease.
Library construction and genome sequencing efforts originally began at Genome Therapeutics Corporation and were transferred to Agencourt Bioscience upon its acquisition of the GenomeVision(TM) Services division of Genome Therapeutics. Upon moving to Agencourt, the work on the rat genome continued with the sequencing of the Rat Y chromosome. In addition to Agencourt, the other major sequencing centers include the Baylor College of Medicine Baylor College of Medicine is a private medical school located in Houston, Texas, USA on the grounds of the Texas Medical Center. It has been consistently rated the top medical school in Texas and among the best in the United States. and Celera Genomics Group of Applera Corp. Additional contributors to the manuscript focused on BAC BAC
blood alcohol concentration library production, fingerprinting, end sequencing, and genome analysis and annotation.
"Sequencing of the third complete mammalian genome is a major accomplishment for both our team and the other contributors. We are pleased that this important analysis of the rat genome will be available to researchers to advance understanding of human disease," said Douglas Smith, Ph.D., Principal Investigator and Director of Grants and Contracts at Agencourt. "Agencourt is now applying the experience we gained in sequencing portions of the human and rat genomes towards the sequencing of genomes of biomedically important organisms as part of the NHGRI NHGRI National Human Genome Research Institute Large-Scale Sequencing network."
NHGRI is one of 27 institutes and centers at the National Institutes of Heath, which is an agency of the Department of Health and Human Services Noun 1. Department of Health and Human Services - the United States federal department that administers all federal programs dealing with health and welfare; created in 1979
Health and Human Services, HHS . NHGRI's Division of Extramural extramural /ex·tra·mu·ral/ (-mur´il) situated or occurring outside the wall of an organ or structure.
situated or occurring outside the wall of an organ or structure. Research supports grants for research, and for training and career development at sites nationwide.
About Agencourt Bioscience Corporation
Agencourt Bioscience Corporation is a provider of genomic services and nucleic acid purification products that help biotech and pharmaceutical companies improve the effectiveness and efficiency of their drug development pipelines. Agencourt's Discovery Solutions(TM) suite of genomic and functional genomic services includes high-throughput sequencing, SAGE(TM) sequencing, library construction and SNP SNP Scottish National Party
Noun 1. SNP - (genetics) genetic variation in a DNA sequence that occurs when a single nucleotide in a genome is altered; SNPs are usually considered to be point mutations that have been evolutionarily discovery. The company's purification products and services are based on the proven and patented Solid Phase Reversible Immobilization Immobilization Definition
Immobilization refers to the process of holding a joint or bone in place with a splint, cast, or brace. This is done to prevent an injured area from moving while it heals. (SPRI SPRI Scott Polar Research Institute (University of Cambridge)
SPRI Single Ply Roofing Institute
SPRI Schering-Plough Research Institute (Corporate division) (TM)) technology, which has been adopted by several of the largest genome research facilities, resulting in more base pairs contributed to GenBank than any other nucleic acid purification technology and used to sequence over one-third of the human genome. Agencourt was recently the sole commercial sequencing provider to be designated by the National Human Genome Research Institute (NHGRI) as one of five Large-Scale Sequencing Centers. The company has also been confirmed to be operating in compliance with the requirements of the Good Laboratory Practices (GLP See gateway location protocol. ) as a contract analytical laboratory. Agencourt is located in Beverly, Massachusetts and is available on the Web at www.agencourt.com.