Agencourt Bioscience Publishes Protein-Protein Interaction Map of Rickettsia Sibirica Virulence-Related Proteins.Business Editors/Health/Medical Writers BEVERLY, Mass.--(BUSINESS WIRE)--March 1, 2004 Utilization of High-Throughput Sequencing and Novel Bacterial Two-Hybrid Technology Leads to Enhanced Understanding of Genome Agencourt Bioscience Corporation, a provider of genomic services and nucleic acid purification products to the life sciences industry, today announced the publication of a genome-wide protein-protein interaction map of virulence-related genes in Rickettsia rickettsia (rĭkĕt`sēə), any of a group of very small microorganisms, many disease-causing, that live in vertebrates and are transmitted by bloodsucking parasitic arthropods such as fleas, lice (see louse), and ticks. sibirica determined using a bacterial two-hybrid system. The work will be published in the March 2004 edition of Nucleic Acids Research Nucleic Acids Research or NAR is a peer reviewed scientific journal published by Oxford University Press. NAR publishes research on Nucleic Acids, such as DNA and RNA, and related work. Some of its content is available under and open access license. (Nucl. Acids. Res. 2004 32: 1059-1064). In 2002, Agencourt, in collaboration with researchers at the Centers for Disease Control and Prevention Centers for Disease Control and Prevention (CDC), agency of the U.S. Public Health Service since 1973, with headquarters in Atlanta; it was established in 1946 as the Communicable Disease Center. (CDC See Control Data, century date change and Back Orifice. CDC - Control Data Corporation ) in Atlanta and the University of Maryland University of Maryland can refer to:
"While the bacterial two-hybrid technology has proven reliable for interactions of individual selected proteins, this is the first report describing the use of this technology to examine large-scale protein interaction mapping on the whole genome level," said Mr. Malek, Senior Manager of Genomics and Proteomics at Agencourt Bioscience Corporation. "This research demonstrates the utility of bacterial two-hybrid systems for large-scale protein mapping as an alternative to other protein mapping technologies." "This technology is a significant advancement towards streamlining genomics and proteomics. A single shotgun library can be constructed and used effectively for both de novo genome sequencing and bacterial two-hybrid protein mapping," said Kevin McKernan, Co-Chief Scientific Officer at Agencourt. "Offering a bacterial two-hybrid service will provide researchers easier access to this powerful protein mapping technology." Rickettsia sibirica is one of 16 Rickettsia species that are known to cause human disease in regions around the world. In the United States, infections with rickettsiae are known to cause diseases such as Rocky Mountain spotted fever Rocky Mountain spotted fever, infectious disease caused by a rickettsia. The germ is harbored by wild rodents and other animals and is carried by infected ticks that attach themselves to humans. , rickettsialpox and murine typhus. About Agencourt Bioscience Corporation Agencourt Bioscience Corporation is a provider of genomic services and nucleic acid purification products that help biotech and pharmaceutical companies improve the effectiveness and efficiency of their drug development pipelines. Agencourt's Discovery Solutions(TM) suite of genomic and functional genomic services includes high-throughput sequencing, SAGE(TM) sequencing, library construction and SNP discovery. The company's purification products and services are based on the proven and patented Solid Phase Reversible Immobilization Immobilization Definition Immobilization refers to the process of holding a joint or bone in place with a splint, cast, or brace. This is done to prevent an injured area from moving while it heals. (SPRI SPRI Scott Polar Research Institute (University of Cambridge) SPRI Single Ply Roofing Institute SPRI Schering-Plough Research Institute (Corporate division) (TM)) technology, which has been adopted by several of the largest genome research facilities, resulting in more base pairs contributed to GenBank than any other nucleic acid purification technology and used to sequence over one-third of the human genome. Agencourt was recently the sole commercial sequencing provider to be designated by the National Human Genome Research Institute (NHGRI NHGRI National Human Genome Research Institute ) as one of five Large-Scale Sequencing Centers. The company has also been confirmed to be operating in compliance with the requirements of the Good Laboratory Practices (GLP See gateway location protocol. ) as a contract analytical laboratory. Agencourt is located in Beverly, Massachusetts and is available on the Web at www.agencourt.com. |
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