Aegis Therapeutics and Albany Medical College Combine Discoveries to Create a Novel Anti-Obesity Nasal Spray.
"Following the discovery of the hormone leptin and its critical role in curbing appetite by Jeffrey Friedman and his colleagues in 1995, many believed that the ability to treat obesity was imminent," said Edward T. Maggio, Ph.D., President and CEO of Aegis. "As a result several clinical trials ensued to combat obesity with recombinant leptin, but these were unsuccessful. This joint agreement between Aegis Therapeutics and Albany Medical College brings renewed hope that a pharmaceutical treatment for obesity is possible."
Researchers at Albany Medical College, in Albany, NY, made an important additional discovery in 2000. Principal investigator, Patricia Grasso, Ph.D., associate professor, Center for Cell Biology and Cancer Research, and Department of Medicine, and co-investigators, Daniel Lee, M.D., associate professor of medicine, and Matthew Leinung, M.D., associate professor of medicine and head of the division of endocrinology and metabolism, found that a very small piece of the leptin hormone, a peptide representing less than 6% of the total leptin molecule, was responsible for controlling appetite. This was found using a synthetic peptide strategy to map the entire leptin molecule for active sites.
At the same time, Aegis Therapeutics has developed a novel, highly effective, intranasal absorption agent for proteins and peptides, termed Intravail(TM), which is creating new therapeutic options for physicians and patients. "Peptides, which are digested in the stomach, cannot be taken orally," said Maggio. "As a result, peptide drugs, such as insulin, human growth hormone, and erythropoietin, are administered by injection. While intranasal administration of protein and peptide drugs has shown some initial success with small peptides such as calcitonin, Aegis' Intravail(TM) absorption enhancement agents provide unmatched bioavailabilities -- bioavailabilities comparable to injection for small as well as much larger proteins, for the first time. This marks an important advance in non-invasive peptide and protein drug delivery in general and will be especially valuable in bringing 'user-friendly' peptide-based anti-obesity therapies to market."
The number of peptides having important biological activities continues to grow at an accelerating rate, with more than 700 new peptide drugs currently reported to be in preclinical development.
About Aegis Therapeutics
Aegis Therapeutics Inc. is a specialty pharmaceutical company commercializing its patented Intravail(TM) drug delivery technology that enables the non-invasive delivery of a broad range of protein, peptide and non-peptide macromolecular therapeutics that can currently only be administered by injection. Aegis' Intravail(TM) absorption enhancement agents are mild and non-irritating to mucosal membranes. They provide exceptionally high and unmatched bioavailability performance, comparable in efficiency to subcutaneous injection, via the intranasal and other mucosal membrane administration routes.
About Albany Medical College
Albany Medical College is part of Albany Medical Center, which also includes the Albany Medical Center Hospital and the Albany Medical Center Foundation, Inc. The institution has a three-fold mission of patient care, biomedical research and medical education.
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|Date:||May 16, 2005|
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