Advancetech Monitor to Release Their Industry Perspective On Predictive Toxocology.Business/Technology Editors WOBURN, Mass.--(BUSINESS WIRE)--Nov. 1, 2000 Advancetech Monitor's (ATM's) www.advancetechmonitor.com industry perspective provides insights on pre-clinical testing, profiling tools and in silico models for successful early lead selection and drug development. ATM's Predictive Toxicology report is available in a 300-page hard copy including CD-ROM CD-ROM: see compact disc. CD-ROM in full compact disc read-only memory Type of computer storage medium that is read optically (e.g., by a laser). with over (100+) plus weblinks and (150+) figures. Learn about the Newest Case Studies and Industry Views on: --Models for the Prediction of Metabolic Drug-Drug Interactions --Human Hepatocytes, Induction of Drug Metabolizing Enzymes and Prediction of Drug-Drug Interactions --Higher-Throughput In Vitro in vitro /in vi·tro/ (in ve´tro) [L.] within a glass; observable in a test tube; in an artificial environment. in vi·tro adj. In an artificial environment outside a living organism. Evaluation of Potential Drug-Drug Interactions Using Human Liver Microsomes in Drug Discovery --Human In Vitro Experimental Systems for ADME-Tox Evaluation --New Analytical and In Vitro Techniques Enable Higher Throughput in Predictive ADME ADME Absorption, Distribution, Metabolism, and Excretion ADME Association of Destination Management Executives ADME Active Duty Medical Extension Studies --A Predictive Model for Estimating Oral Bioavailability bioavailability /bio·avail·a·bil·i·ty/ (bi?o-ah-val?ah-bil´i-te) the degree to which a drug or other substance becomes available to the target tissue after administration. bi·o·a·vail·a·bil·i·ty n. of Drugs from Their In Vitro ADME Screens --High Throughput In Vitro ADME/TOX Screening Using Lab-on-a-Chip Technology --Case Study: Use of In Silico Knowledge-Based Systems According to the Free On-line Dictionary of Computing (FOLDOC), a knowledge-based system is a program for extending and/or querying a knowledge base. The Computer User High-Tech Dictionary defines a knowledge-based system to Integrate Toxicoinformatics in Drug Discovery and Development --Use of In Silico Approaches as Predictive Toxicology Tools --Computational Toxicity Assessment in Early Drug Discovery and Development -- When is it Viable? --The Use of GeneCalling(TM)-- Differential Gene Expression Technology to Generate Drug-Induced Toxicity Profiles --Use of Gene Expression Profiling Microarray technology is often used for gene expression profiling. It makes use of the sequence resources created by the genome sequencing projects and other sequencing efforts to answer the question, to Characterize Toxicity --ToxExpress -- Gene Expression Profiling for Predictive Toxicology --TaqMan Gene Expression Car Arrays for Accurate Quantification of Toxicology Targets --The Role of Pharmacogenomics Pharmacogenomics is the branch of pharmacology which deals with the influence of genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with a drug's efficacy or toxicity. in Toxicology Testing --Pharmacogenomics and Drug Response --Pharmacogenomic Profiling to Design Safe and Efficient Clinical Trials --The Development of Profiling Tools for Early Lead Selection --In Vivo Toxicity Screens for Successful Early Lead Optimization --Use of FDA FDA abbr. Food and Drug Administration FDA, n.pr See Food and Drug Administration. FDA, n.pr the abbreviation for the Food and Drug Administration. Databases and Computational Toxicology to Predict Toxicity --A Consortium Approach to Building a Toxicology Database from Proprietary Compounds Advancetech Monitor (ATM) reports give you a unique advantage. Simply put, this means you have One Central Resource for Toxicology at your fingertips "Fingertips" is a 1963 number-one hit single recorded live by "Little" Stevie Wonder for Motown's Tamla label. Wonder's first hit single, "Fingertips" was the first live, non-studio recording to reach number-one on the Billboard Pop Singles chart in the United States. through the purchase of only one ATM publication. With the glut of information in the market today, why not streamline your research and your ability to make timely, strategic decisions? Get the ATM Advantage ... one comprehensive resource that save you both time and money and provides you with collective expert opinions that you will find nowhere else. For more information about ATM please visit our website at www.advancetechmonitor.com or call Cynthia Ashton @ 781-939-2418. |
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