Advanced Biotherapy AIDS study.Woodland Hills based Advanced Biotherapy biotherapy /bio·ther·a·py/ (-ther´ah-pe) biological therapy. bi·o·ther·a·py n. Treatment of disease with biologicals, such as vaccines. Inc. announced the launch of a phase I FDA-approved clinical trial to initially treat antiretroviral drug-resistant AIDS patients. The trial is being conducted by researchers at Georgetown University. The study's enrollment at the onset is limited by 10 patients who are in virologic failure virologic failure Antiretroviral therapy failure, see there and no longer able to benefit from the administration of highly active anti-retroviral therapy. It is estimated that more than 50 percent of AIDS patients ultimately become non-responsive to such drugs during the course of their treatment. Advanced Biotherapy's plan is to use an inhibitor that targets TNF-alpha, a pro-inflammatory cytokine Cytokine Any of a group of soluble proteins that are released by a cell to send messages which are delivered to the same cell (autocrine), an adjacent cell (paracrine), or a distant cell (endocrine). , that severely disturbs the body's immune system immune system Cells, cell products, organs, and structures of the body involved in the detection and destruction of foreign invaders, such as bacteria, viruses, and cancer cells. Immunity is based on the system's ability to launch a defense against such invaders. . The new Phase I study is intended to test the safety and possibly show a clinical effect of this inhibitor aimed at helping to restore normal immune system function in AIDS patients with advanced disease. |
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