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Advanced BioHealing and Leading Researchers Release Data from Landmark Wound Care Analysis.


Results Support Value of Serial Debridement Debridement Definition

Debridement is the process of removing nonliving tissue from pressure ulcers, burns, and other wounds.
Purpose

Debridement speeds the healing of pressure ulcers, burns, and other wounds.
 in Chronic Wounds

PHILADELPHIA -- Advanced BioHealing, Inc. (ABH ABH Actual Bodily Harm
ABH American Board of Hypnotherapy
ABH Anywhere But Here (fan fiction mode)
ABH Agentschap voor Buitenlandse Handel
ABH Aviation Boatswain's Mate (aircraft handling) 
), in collaboration with leaders in wound healing wound healing Physiology The repair of a wound Steps Inflammation, repair and closure, remodeling, final healing; repair of incisions may be either simple–'clean' wounds with little loss of tissue heal by 'primary intention', or 'dirty' wounds heal by  research, today released an analysis that demonstrates the value of serial debridement in treating lower extremity lower extremity
n.
The hip, thigh, leg, ankle, or foot. Also called inferior limb, pelvic limb.
 wounds. The manuscript, entitled "Serial Surgical Debridement Increases the Healing Rates of Chronic Lower Extremity Wounds," was presented by David Armstrong, DPM (Documents Per Minute) The number of paper documents that can be processed in one minute. , Ph.D, at the annual meeting of the American Podiatric Medical Association (APMA APMA American Podiatric Medical Association
APMA Automotive Parts Manufacturers' Association
APMA Australian Pharmaceutical Manufacturers Association
APMA American Preventive Medical Association
APMA Australian Packaging Machinery Association
) in Philadelphia, Pa.

"We looked at data from more than 500 patients who were enrolled in two large clinical studies of wound healing," said Dr. Armstrong, Professor of Surgery and Director of Scholl's Center for Lower Extremity Ambulatory Research (CLEAR) at Rosalind Franklin University of Medicine and Science History
In 1912, a group of physicians and community leaders formed a non-profit school, then known as The Chicago Hospital-College of Medicine, to serve medical students who were able to attend only at night.
 in Chicago. "The results clearly demonstrate the value of serial wound debridement to increase the rate of wound healing and the likelihood of total wound closure. We are gratified grat·i·fy  
tr.v. grat·i·fied, grat·i·fy·ing, grat·i·fies
1. To please or satisfy: His achievement gratified his father. See Synonyms at please.

2.
 that Advanced BioHealing is partnering with physicians to help us improve patient outcomes and willing to allow access to these large databases it has collected while conducting clinical studies."

Examination of data from the clinical trials revealed that wounds serially debrided within the first four weeks of the treatment period had a median wound area reduction 54 percent higher than wounds that were not debrided. Additionally, venous leg ulcers receiving debridement at more than half of their study visits in the first month had a better chance of reaching 75 percent wound closure in 4 weeks, 90 percent wound closure in 12 weeks, and/or 100 percent closure in 12 weeks. Diabetic foot diabetic foot A foot with a constellation of pathologic changes affecting the lower extremity in diabetics, often leading to amputation and/or death due to complications; the common initial lesion leading to amputation is a nonhealing skin ulcer, induced by  ulcers receiving debridement at every study visit over 12 weeks had a much greater chance of reaching ultimate wound closure than those debrided less often.

David Eisenbud, MD, Vice President and Chief Medical Officer of ABH, added, "We believe that our products, such as Dermagraft([R]), are most effective when used within a comprehensive regimen that optimizes the wound healing process. It benefits the company, physicians, and patients for us to mine our extensive databases for empirical evidence to guide clinical care." He also noted, "The value of serial debridement has been a somewhat controversial topic throughout the years. We believe these data conclusively demonstrate the importance of this clinical procedure in facilitating closure of chronic wounds."

This research is part of an on-going collaboration between ABH, leading medical scientists, and institutions to use the company's data, accumulated through multiple large registration trials, to answer important clinical questions and advance evidence-based wound care.

ABOUT ADVANCED BIOHEALING, INC.

Advanced BioHealing is an industry leader in the science of regenerative medicine. The company is focused on the commercialization of cell-based and tissue-engineered products. It currently markets the FDA-approved product Dermagraft([R]) for diabetic foot ulcers. Additionally, the company's development pipeline includes a next-generation bioengineered tissue product, which is in clinical trials. ABH is a privately held company privately held company

A firm whose shares are held within a relatively small circle of owners and are not traded publicly.
 with research and development offices in New York, N.Y., and manufacturing operations in La Jolla, Calif. For more information about ABH visit www.AdvancedBioHealing.com
COPYRIGHT 2007 Business Wire
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Copyright 2007, Gale Group. All rights reserved.

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Publication:Business Wire
Article Type:Clinical report
Date:Aug 16, 2007
Words:503
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