Adaptive design methods in clinical trials.1584887761 Adaptive design methods in clinical trials. Chow, Shein-Chung and Mark Chang Mark Chang, the Prince of Yugopotamia, (which could possibly be a portmeantau for Mesopotamia and Yugoslavia) is a fictional character in the Nickelodeon animated television series The Fairly OddParents. His name might be a spoof of Marcus Chong. . Chapman & Hall/CRC 2007 277 pages $89.95 Hardcover Biostatistics biostatistics /bio·sta·tis·tics/ (-stah-tis´tiks) biometry. bi·o·sta·tis·tics n. The science of statistics applied to the analysis of biological or medical data. ; 17 R853 Adapting the trial and/or statistical procedure of on-going clinical trials based on accrued ac·crue v. ac·crued, ac·cru·ing, ac·crues v.intr. 1. To come to one as a gain, addition, or increment: interest accruing in my savings account. 2. data--for example all the subjects dying--has been common practice for years, but regulators look a little askance a·skance also a·skant adv. 1. With disapproval, suspicion, or distrust: "The area is so dirty that merchants report the tourists are looking askance" Chris Black. at it. Chow (medicine, Duke U. and National Cheng-Kung U., Taiwan) and Chang, with a Massachusetts pharmaceutical company, suggest that if the trial were designed from the beginning to be adapted, the US Food and Drug Administration might be less skeptical. They explain how to incorporate into trial design possible adaptation in such areas as protocol, group sequence, sample size, and treatment switching. ([c]20072005 Book News, Inc., Portland, OR) |
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