Active Biotech: Interim Report January - March 2001.Business Editors LUND, Sweden--(BUSINESS WIRE)--May 14, 2001 - Q2 Interim Report August 8 - Q3 Interim Report November 6 - The preliminary yearend report for 2001 will be published on February 14, 2002. Active Biotech plans to separate and further streamline its operations, investing heavily in the project portfolios while focusing on a partner strategy. The operations of Active Biotech currently focus on the development of pharmaceuticals and vaccines. In Lund, the company conducts pharmaceutical research and development and has very promising projects, particularly in the fields of MS and cancer. The company's operations in Stockholm involve developing, manufacturing and marketing vaccines against diseases such as polio, cholera and tourist diarrhoea (ETEC ETEC enterotoxigenic Escherichia coli. ETEC Enterotoxic Escherichia coli, see there ). The ongoing development of these operations requires a variety of strategies and skills, and the co-ordination gains to be made between the operations in Lund and Stockholm are therefore limited. At today's meeting, the Board of Directors of Active Biotech decided that the operations should be streamlined and divided into two clearly defined subsidiaries, Active Biotech Research and SBL SBL Society of Biblical Literature SBL Symbol Technologies, Inc. (NYSE symbol) SBL Spamhaus Block List SBL Space-Based Laser SBL Securities Borrowing and Lending SBL Supreme Beings of Leisure (band) Vaccin, each with its own management team and separate organisation. A smaller Group-wide management team will be responsible for overall co-ordination of the Active Biotech Group. The main focus of both units' strategies was approved. For both units, it involves explicit partner strategies. The company plans to allocate considerable resources and investments to the project platforms described below. The initiative is to be financed through partnership agreements and the possible sale of the SBL operations. The company will also start preparations for a potential new share issue. Active Biotech Research The general view is that the best way of promoting future value growth at the Active Biotech Group is through a broader, dynamic initiative focusing on the activities conducted at Active Biotech Research in Lund. On the basis of the decision made at today's Board meeting, operations will be reorganised into three platforms. The idea is to clarify the company's strategy and goals and facilitate the establishment of joint efforts the company has either already agreed or will be seeking in a variety of areas. One of the three platforms, the TTS (1) See text-to-speech. (2) (Transaction Tracking System) Software that monitors a transaction until completion. In the event of a hardware or software failure, it ensures that the database is brought back to its former state before the attempt to platform, focuses on biologicals (biotechnology products), while the so-called Q and B platforms focus on the development of small molecules (low molecular weight chemicals). The Q Platform The company's Q platform forms a basis for the development of pharmaceuticals used in the treatment of both inflammatory autoimmune diseases Autoimmune diseases A group of diseases, like rheumatoid arthritis and systemic lupus erythematosus, in which immune cells turn on the body, attacking various tissues and organs. Mentioned in: Complement Deficiencies, Premature Menopause and cancer. The project that has made most progress in this platform area focuses on developing a drug in tablet form for use in treating multiple sclerosis, SAIK-MS. Active Biotech announced at the end of April that the clinical goal of the Phase I study of SAIK-MS had been attained in a highly satisfactory manner. The study was conducted in the form of a dose escalation study aimed at determining the highest dose that can safely be administered to MS patients. The study included 35 healthy volunteers and 11 MS patients, and the Maximum Tolerable Dose maximum tolerable dose The highest dose of a substance that can be given without causing serious weight loss or other signs of toxicity. See Maximum contaminant level. (MTD MTD Mounted MTD Maximum Tolerated Dose MTD Memory Technology Device MTD Month To-Date MTD Methadone (drug screening) MTD motion to dismiss (legal) MtD Mountain Dew MTD Memory Technology Driver ) was set at 1.2 mg/day, after patients showed uniform signs of inflammatory reactions to the higher dose of 2.4 mg/day. This means that the safety margin for SAIK-MS is good, since the estimated therapeutic dose level is 0.03-0.3 mg/day. Discussions are being held with potential partners with the aim of initiating joint efforts centering on SAIK-MS. There is considerable interest in this project. Since development is still at a relatively early stage, it is important to find the right partner and the right form of co-operation so as to ensure optimal value growth. Alongside these discussions, a Phase II study is also being planned to ensure that the project work proceeds without losing momentum. Within the framework of the Q platform activities, a co-operation agreement was reached on April 17, 2001 between Active Biotech and Dr. John T. Isaacs of the Johns Hopkins University Johns Hopkins University, mainly at Baltimore, Md. Johns Hopkins in 1867 had a group of his associates incorporated as the trustees of a university and a hospital, endowing each with $3.5 million. Daniel C. in Baltimore (U.S.) with the aim of developing a product candidate for use in the treatment of prostate cancer prostate cancer, cancer originating in the prostate gland. Prostate cancer is the leading malignancy in men in the United States and is second only to lung cancer as a cause of cancer death in men. . Prostate cancer is the form of cancer with the highest mortality rate after lung cancer lung cancer, cancer that originates in the tissues of the lungs. Lung cancer is the leading cause of cancer death in the United States in both men and women. Like other cancers, lung cancer occurs after repeated insults to the genetic material of the cell. . At the early stages, when the disease is hormone- dependent, treatment usually involves orchiectomy orchiectomy /or·chi·ec·to·my/ (or?ke-ek´tah-me) excision of one or both testes. If bilateral it is called also castration. or·chi·ec·to·my or or·chi·dec·to·my n. or chemical castration chemical castration Pharmacologic castration Public health The treatment of ♂ with paraphilia with methoxyprogesterone acetate, which inhibits gonadotropin secretion. See Chemical castration, Megan's law, Pedophilia. . When the disease progresses and is no longer hormone- dependent, there are currently no effective treatment methods available. The co-operation will involve the Johns Hopkins University using experimental models of prostate cancer to evaluate the effect of a series of substances developed by Active Biotech. A product candidate will be selected on the basis of this work. Active Biotech has submitted patent applications for the relevant substances and their use in the treatment of prostate cancer. Other activities based on the Q platform aim to develop product candidates for use in treating other inflammatory/autoimmune diseases and to define molecules and mechanisms that interact with the Q substances to produce their biological effects. The TTS Platform The cancer project known as TTS (Tumor Targeted Superantigens) was previously conducted in the form of contract research on behalf of Pharmacia. At the end of 1999, all rights to the project were acquired with the aim of taking the project to the evaluation stage under the company's own auspices. The TTS project was evaluated during 2000, and a Phase I clinical trial Noun 1. phase I clinical trial - a clinical trial on a few persons to determine the safety of a new drug or invasive medical device; for drugs, dosage or toxicity limits should be obtained phase I on a product candidate for use in the treatment of renal cancer and non small-cell lung cancer was completed. We are now awaiting the final report on the study, but the preliminary data looks promising. In addition, extensive development work is under way on the next generation of TTS products. Since TTS as a concept can be used against other forms of cancer, work is also under way to develop TTS products for other indications. The company is now actively proceeding with the TTS project and is entering Phase II, and renewed efforts and investments are being devoted to it. Active Biotech intends to begin negotiations during the year with Pharmacia pursuant to the options agreement previously reached. The upcoming clinical Phase II trials are being planned in co-operation with the Karolinska Hospital in Stockholm and Christie Hospital The Christie Hospital NHS Foundation Trust is located in Withington, Manchester, and is one of the largest cancer treatment centres in Europe. The hospital is also an international leader in cancer research and development, and home to The Paterson Institute for Cancer in Manchester and are expected to start during the second half of 2001. The B Platform In the B platform area in 2000, Active Biotech produced a new basis for the development of pharmaceuticals for use in the treatment of autoimmune/inflammatory diseases and cancer. One patent application has been submitted thus far in this platform area, and additional applications are being prepared. The two most advanced subprojects in the B platform area aim to develop pharmaceutical candidates for use in the treatment of inflammatory bowel disease inflammatory bowel disease n. Abbr. IBD Any of several incurable and debilitating diseases of the gastrointestinal tract characterized by inflammation and obstruction of parts of the intestine. (IBD IBD abbr. inflammatory bowel disease Inflammatory bowel disease (IBD) Disease in which the lining of the intestine becomes inflamed. Mentioned in: Amebiasis IBD 1. ) and rheumatoid arthritis rheumatoid arthritis Chronic, progressive autoimmune disease causing connective-tissue inflammation, mostly in synovial joints. It can occur at any age, is more common in women, and has an unpredictable course. (RA). These two chronic diseases affect a large group of people in the West. Other Projects In addition to the above platforms, other projects are proceeding as planned. SBL Vaccin (SBL) Compared to Active Biotech Research, the operations in Stockholm have reached a far higher level of maturity, with a number of products on the market or in late development phases (ETEC, Phase III Noun 1. phase III - a large clinical trial of a treatment or drug that in phase I and phase II has been shown to be efficacious with tolerable side effects; after successful conclusion of these clinical trials it will receive formal approval from the FDA ). Ongoing efforts will focus on generating maximal sales of existing and upcoming products. The company will continue to develop its market position in the Nordic region and to broaden its international market penetration Noun 1. market penetration - the extent to which a product is recognized and bought by customers in a particular market penetration - the act of entering into or through something; "the penetration of upper management by women" through close co-operation with major international companies with strong market organisations. Joint efforts have already been introduced in some markets, with Aventis Pasteur (international markets) and Aventis Pasteur MSD (MicroSoft Diagnostics) A utility that accompanied Windows 3.1 and DOS 6 that reported on the internal configuration of the PC. A variety of information on disks, video, drivers, IRQs and port addresses was provided. (the Nordic region). Apart from the expenses involved in the current Phase III studies of a new vaccine against tourist diarrhoea (ETEC), SBL has no plans for any major investments in new projects or manufacturing plants. The company's expenses will mainly be attributable to product manufacturing, as well as marketing and sales in the Nordic region. Income from sales is expected to increase rapidly now that the SBL Cholera Vaccine and Dukoral are being launched in new markets, while cost increases will be limited. The intent is for SBL to find joint efforts in areas other than those devoted solely to the marketing of existing products. Among other things, SBL intends to seek partners for the ETEC project and for the completion of the Phase III study, as well as for the international registration and launch of this product, which has a highly interesting market potential. Joint projects are also planned for the development of a paediatric Adj. 1. paediatric - of or relating to the medical care of children; "pediatric dentist" pediatric indication for use in third-world countries. Further efforts in the ETEC project, however, await approval of SBL's application to change the definition of the goal of the study currently under way by U.S. FDA FDA abbr. Food and Drug Administration FDA, n.pr See Food and Drug Administration. FDA, n.pr the abbreviation for the Food and Drug Administration. registration authorities. Diarrhoea Vaccines The process involved in WHO registration of the SBL Cholera Vaccine has now reached the final phase and is expected to be completed during Q4 2001. One of the reasons for this registration is to allow UN organs to use the vaccine and to build up emergency stocks. Medecins sans Frontieres (MSF MSF Manufacturing, Science, and Finance (Union) ) has already built up a small, contingency stock. In a recent WHO publication, WHO renewed its recommendation of the SBL Cholera Vaccine as the only vaccine providing effective protection against cholera. The organisation emphasised that the SBL Cholera Vaccine is well tolerated and verifies the fact that the vaccine also provides good protection against ETEC infection. New Co-operation Agreements On April 1, a new joint effort was entered into with Aventis Pasteur MSD on vaccines in the Swedish market. Since April 1, SBL is also the Danish Statens Seruminstitut's (SSI (1) See server-side include and single-system image. (2) (Small-Scale Integration) Less than 100 transistors on a chip. See MSI, LSI, VLSI and ULSI. 1. (electronics) SSI - small scale integration. 2. ) distributor in Sweden and Norway.
Financial Information
Net Sales
The launch of the SBL Cholera Vaccine initiated last year and the
changes to the agreements on agency and distribution operations in
Sweden and Norway have had a major impact on the sales outcome during
Q1 2001 compared with the previous year.
Jan. - Mar. Sales (%)
Vaccine sales 2001 2000 Change 2001 2000
(%)
Vaccines
manufactured in-house
Dukoral 12,3 11,5 6%
SBL Cholera Vaccine 0,0 6,9 neg
Other products 2,6 3,6 -28%
TOTAL 14,9 22,0 -32% 32% 41%
AGENCY PRODUCTS 0,1 10,6 neg 0% 20%
Distribution orders 31,7 20,7 53% 68% 39%
Total vaccine sales 46,7 53,4 -13% 100.0% 100.0%
INCOME FROM CONTRACT 0,0 10,0
RESEARCH
Other income 0,7 1,1
Total net sales 47,4 64,5 -26%
Sales of Dukoral in the Nordic market rose only 6 percent compared with the previous year as a result of distributors' stock adjustments. Sales to end customers in Sweden and Norway are continuing to perform well, reporting an increase of 17 and 38 percent respectively. Aventis Pasteur is now preparing the launch of the SBL Cholera Vaccine in markets outside the EU/U.S. The registration process is proceeding and applications have been submitted in around 25 countries, with sales expected to start during the second half of the year. During the corresponding period the previous year, a single order totalling SEK SEK In currencies, this is the abbreviation for the Swedish Krona. Notes: The currency market, also known as the Foreign Exchange market, is the largest financial market in the world, with a daily average volume of over US $1 trillion. 6.9 million was invoiced to Mozambique. Agency operations The windup of the GlaxoSmithKline partnership at the end of 2000 and the agreement with Aventis Pasteur MSD that came into force on April 1, 2001, led to a short-term decline in sales during Q1, when no invoicing was registered. Sales have begun very well for the Aventis Pasteur MSD travel-vaccination program. Distribution orders are displaying excellent growth, with sales jumping 53 percent to SEK 31.7 million. The increase in sales is mainly attributable to volume growth for existing and new operations. Group Financial Results The accounting principles used to report research expenses in the Group were harmonised Adj. 1. harmonised - involving or characterized by harmony consonant, harmonical, harmonized, harmonic harmonious - musically pleasing at the end of the year. This has entailed booking all expenses related to the diarrhoea-vaccine projects as costs as they arise. In the corresponding period the previous year, the expenses involved in these projects were capitalised. As a consequence of the take-over of all rights to the TTS project from Pharmacia, continued clinical development is being conducted in-house and previous agreements concerning contract research ceased to apply as of December 2000. The operating loss operating loss The excess of operating expenses over revenue. As with operating income, operating losses exclude revenues and expenses from operations that are not considered a regular part of the business. Also called deficit. Compare operating income. before financial items totalled SEK -87.6 million (SEK -51.5 m), while the adjusted pro forma As a matter of form or for the sake of form. Used to describe accounting, financial, and other statements or conclusions based upon assumed or anticipated facts. The phrase pro forma loss for the corresponding period the previous year was SEK -67.8 million. The change in the financial result can be attributed mainly to the fall in income from contract research in the TTS cancer project (SEK 10 million) after the Pharmacia agreement ceased at year end, as well as to higher research expenses as the prioritised projects proceed to new clinical phases according to according to prep. 1. As stated or indicated by; on the authority of: according to historians. 2. In keeping with: according to instructions. 3. plan. The short-term decline in sales income during Q1 is attributable to the fact that Aventis Pasteur took over the international marketing of the SBL Cholera Vaccine and that the GlaxoSmithKline agency agreement ended on December 31, 2000. Despite this, the gross profit and the gross profit margin Gross profit margin Gross profit divided by sales, which is equal to each sales dollar left over after paying for the cost of goods sold. gross profit margin A measure calculated by dividing gross profit by net sales. on vaccine sales improved, compared with the corresponding period the previous year. Operating expenses Operating expenses The amount paid for asset maintenance or the cost of doing business, excluding depreciation. Earnings are distributed after operating expenses are deducted. , excluding the cost of goods sold Cost of goods sold The total cost of buying raw materials, and paying for all the factors that go into producing finished goods. cost of goods sold , rose 13 percent to SEK 102 million (SEK 74 million). The adjusted pro forma figure is SEK 91 million. The difference is attributable to the continued positive performance of the prioritised research projects, SAIK-MS, TTS and ETEC, which have, as expected, led to increased costs, since SAIK-MS and TTS have now completed Phase I tests and the ETEC project is proceeding to Phase III. Altogether, sales, administrative and other income/expenses have fallen marginally. The Group's net financial items fell from SEK 76.5 million in 2000 to SEK 1.0 million this year. This reflects realised profits made in the Zenit hedge fund hedge fund, in finance, a highly speculative, largely unregulated investment device. Originating in the 1950s, the funds "hedge" by offsetting "short" positions (borrowing a security and then selling it at a higher price before repaying the lender) against "long" during Q1 last year. The operating loss after net financial items totalled SEK -86.6 million (SEK 25.0 million), while the previous year's adjusted pro forma profit came to SEK 8.7 million. Financial Status The Group's equity/assets ratio on March 31, 2001, was 69.3 percent (74.3 percent on December 31, 2000). The company had no loans at the end of Q1. Cash flow for Q1 came to SEK -89 million (SEK 37 million), which is explained by the financial result for the period, as well as investments in production facilities designed to meet future sales growth, and a positive change in operating capital. The Group's liquid assets Cash, or property immediately convertible to cash, such as Securities, notes, life insurance policies with cash surrender values, U.S. savings bonds, or an account receivable. totalled SEK 319 million at the end of the reporting period (SEK 408 million on December 31, 2000). In addition, credit lines have been granted, but not utilised, in a total amount of SEK 30 million. Shareholders' equity Shareholders' Equity A firms' total assets minus its total liabilities. Equivalently, it is share capital plus retained earnings minus treasury shares. Shareholders' equity is the amount by which a company is financed through common and preferred shares. in the Group totalled SEK 547 million at the end of the reporting period (SEK 646 million on December 31, 2000). The company currently has no plans to publish a forecast for the full year 2000, as it will be influenced by the outcome of ongoing business discussions. Accounting and Valuation Principles This Interim Report has been drawn up pursuant to the same principles as those used in the latest Annual Report. Upcoming Financial Information - Q2 Interim Report August 8 - Q3 Interim Report November 6 - The preliminary yearend report for 2001 will be published on February 14, 2002. Lund May 9, 2001 Active Biotech AB (publ) Sven Andreasson President & CEO (1) (Chief Executive Officer) The highest individual in command of an organization. Typically the president of the company, the CEO reports to the Chairman of the Board. The company's auditors have not reviewed this Interim Report. Active Biotech is a biotechnology company focusing on research in and development of pharmaceuticals and vaccines. Our expertise lies in our in-depth knowledge of the human immune system immune system Cells, cell products, organs, and structures of the body involved in the detection and destruction of foreign invaders, such as bacteria, viruses, and cancer cells. Immunity is based on the system's ability to launch a defense against such invaders. . We have a high-quality project portfolio with significant value potential. Important products and projects include drugs for use in treating multiple sclerosis (SAIK SAIK Sandvikens Aik ) and cancer (TTS), as well as the cholera vaccine, SBL Cholera Vaccine and the tourist diarrhoea vaccines, Dukoral and ETEC. Active Biotech's net sales Net Sales The amount a seller receives from the buyer after costs associated with the sale are deducted. Notes: This amount is calculated by subtracting the following items from gross sales: merchandise returned for credit, allowances for damaged or missing goods, freight in 2000 totalled SEK 280 million. Active Biotech AB Box 724, S-220 07 Lund, Sweden Tel +46 46-19 20 00 Fax +46 46 19 20 50 E-mail info@activebiotech.com ------------------------------------------------------------ This information was brought to you by BIT http://www.bit.se The following files are available for download: http://www.bit.se/bitonline/2001/05/14/20010514BIT00860/bit0002.doc The full report ------------------------------------------------------------------- http://www.bit.se/bitonline/2001/05/14/20010514BIT00860/bit0002.pdf The full report ------------------------------------------------------------------- |
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