Accelrys and the Cambridge Crystallographic Data Centre Integrate the Cambridge Structural Database System with Materials Studio 4.1.

New Functionality Allows Researchers to Combine Modeling Techniques with Known Information about Crystal Structures to Solve Problems Such as Crystal Structure Determination or Polymorph Prediction

SAN DIEGO -- Accelrys, Inc. (NASDAQ: ACCL) announced the integration of Materials Studio[R] 4.1, a comprehensive suite of PC-based modeling and simulation solutions for studying a wide range of materials properties and processes, with the Cambridge Structural Database (CSD), a principal product of the Cambridge Crystallographic Data Centre (CCDC).

The integration of Materials Studio and the CSD allows for initiation of a CSD search directly from Materials Studio, providing rapid access to atomic coordinate and other information relating to more than 400,000 crystal structures. Alternatively, a substructure query prepared in Materials Studio can be automatically transferred to CCDC's ConQuest interface for subsequent database searches that take advantage of ConQuest's extended search capabilities. Post-search analysis can be conducted in either Materials Studio or ConQuest.

Crystallization plays an important role in various industries as a large-scale technique for separation, purification and structure determination. Many compounds are either sold in their crystalline state or at least crystallized at some point during their production process. Knowledge of crystal structures is a prerequisite for the rational understanding of the solid-state properties of new materials. Crystal structure determination is also required for reliable patent protection of new products.

Dr. Frank Allen, Executive Director of the CCDC, is enthusiastic about the integration with Materials Studio: "The CSD is recognized as the world's repository of organic and metal-organic crystal structure data, holding more than 400,000 structures, with over 30,000 new structures archived annually. The integration of the CSD System with Materials Studio provides access to this evaluated data source on the desktops of materials scientists worldwide. When combined with the tools in Materials Studio, the availability of these data will lead to improved productivity and the faster solution of problems related to crystalline states."

For more information about Materials Studio or to download a free trial of the visualization component, Materials Visualizer, please visit www.accelrys.com.

About Accelrys, Inc.

Accelrys has over twenty years of innovation and technology leadership in delivering software and service solutions that transform discovery and development research. A unique combination of expertise in life and materials science, informatics, and scientific operating platform technologies lets Accelrys serve a diverse range of clients, including some of the world's leading pharmaceutical, biotechnology, chemical, and nanotechnology research organizations. Accelrys is headquartered in San Diego, California. For more information about Accelrys, visit its website at http://www.accelrys.com/.

About the CCDC

The CCDC was founded in 1965 in the University of Cambridge and became an independent non-profit company in 1989. The CCDC is responsible for the creation, maintenance and development of the Cambridge Structural Database of small-molecule crystal structures - among the first numerical databases created anywhere in the world. Today, the CSD System comprises the CSD and associated search, analysis and visualization software, and CSD-derived knowledge bases of structural information. In crystallography, the CCDC co-develops and markets the DASH program for structure solution from powder diffraction data. The CCDC also develops software in the life sciences: GOLD for protein - ligand docking, SuperStar for studying protein - ligand interactions, and Relibase+, a database system for analysing experimental data on protein - ligand complexes. For complete information please visit the CCDC website at http://www.ccdc.cam.ac.uk.

Forward-Looking Statements

This press release contains forward-looking statements. Such statements, including statements relating to the Company's products, including the products' features and potential demand therefore, are subject to risks and uncertainties including, but not limited to, the risks that the products will not be timely or successfully completed, developed or achieve market acceptance, demand relating to these products, and other risks and uncertainties described in documents Accelrys has filed with the Securities and Exchange Commission, including its most recent report on Form 10-K and any subsequent interim filings. All forward-looking statements in this document are qualified entirely by the cautionary statements included in this document and such filings. These risks and uncertainties could cause actual results to differ materially from results expressed or implied by forward-looking statements contained in this document. These forward-looking statements speak only as of the date of this document. Accelrys disclaims any intent or obligation to publicly update or revise any forward-looking statements contained herein to reflect any change in its expectations with regard thereto or any change in events, conditions or circumstances on which any such statement is based.