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Abbott Laboratories Honors Outstanding Scientists and Engineers For Scientific Excellence, Leadership and Innovation.



Abbott Laboratories announced today that 28 Abbott scientists were inducted as new or promoted members to the company's prestigious Volwiler Society for their scientific excellence and leadership. Abbott additionally recognized an outstanding researcher and research team for their scientific leadership and innovation.

Abbott named Jack Henkin, Ph.D. outstanding researcher in recognition of his innovative contributions to Abbott's cancer research programs. Henkin, who resides in Illinois and is a biochemist with a broad-based knowledge of anticancer therapy, was recognized for his clear and measurable understanding of the drug development process and the application of science and technology to the goals of pharmaceutical research. He has championed six molecules in two distinct therapeutic areas that Abbott is using in human clinical trials. In addition, his agents are being pursued for treatment of cancers in companion animals with unprecedented responses in animals with normally terminal disease. He is a research fellow in the Volwiler Society, and has more than 19 years of Abbott service.

Abbott's HUMIRA(R) Discovery, Development and Production team, an internal group within Abbott's Global Pharmaceutical Research and Development organization, was recognized as the Outstanding Research Team for scientific innovation and their contribution to the success of Abbott's new treatment for rheumatoid arthritis rheumatoid arthritis

Chronic, progressive autoimmune disease causing connective-tissue inflammation, mostly in synovial joints. It can occur at any age, is more common in women, and has an unpredictable course.
 (RA). HUMIRA, which received approval from the U.S. Food and Drug Administration (FDA) on Dec. 31, 2002, is the first human monoclonal antibody approved by the FDA for reducing the signs and symptoms and inhibiting the progression of structural damage in adults with moderately to severely active RA. Each team member made a significant contribution to overcoming the challenges that drove HUMIRA's ultimate success. Members of the HUMIRA Discovery, Development and Production team are Hans-Jurgen Krause, Ph.D., Peter Moesta, Ph.D., Achim Moller, Ph.D., Jochen Salfeld, Ph.D., and Brian Turner, Ph.D.

Rheumatoid arthritis is an incurable autoimmune disease autoimmune disease, any of a number of abnormal conditions caused when the body produces antibodies to its own substances. In rheumatoid arthritis, a group of antibody molecules called collectively RF, or rheumatoid factor, is complexed to the individual's own gamma  that causes pain, stiffness and swelling around the joints, and can lead to disability and premature death Premature Death occurs when a living thing dies of a cause other than old age. A premature death can be the result of injury, illness, violence, suicide, poor nutrition (often stemming from low income), starvation, dehydration, or other factors. . With RA, the immune system immune system

Cells, cell products, organs, and structures of the body involved in the detection and destruction of foreign invaders, such as bacteria, viruses, and cancer cells. Immunity is based on the system's ability to launch a defense against such invaders.
 attacks healthy tissue, particularly those that line and cushion joints. More than two million Americans, and five million people worldwide, live with this crippling disease.

In keeping with Abbott Laboratories' long history of philanthropy, in addition to individual recognition, outstanding research honorees each receive a monetary award for donation to any college or university of their choice.

"Excellence in scientific innovation is central to our business of bringing promising new products to patients in therapeutic areas of significant unmet medical need," said Jeff M. Leiden, M.D., Ph.D., president and chief operating officer Chief Operating Officer (COO)

The officer of a firm responsible for day-to-day management, usually the president or an executive vice-president.
, pharmaceutical products group, and chief scientific officer, Abbott Laboratories. "This year's honorees demonstrate a powerful combination of leadership, expertise and creativity."

Abbott Laboratories established the Volwiler Society in 1985 to recognize the company's most distinguished scientists and engineers. Named for the late Ernest H. Volwiler Ernest H. Volwiler (August 22, 1893-October 3, 1992) spent his entire career at Abbott Laboratories working his way from staff chemist to CEO.

A Hamilton, Ohio native, Volwiler received a bachelor's degree from Miami University in Oxford, Ohio and a Masters degree and Ph. D.
, Ph.D., a scientist and former Abbott president and chairman of the board, the society encourages professional growth and constant pursuit of innovation and scientific discovery. Dr. Volwiler is recognized in the National Inventors Hall of Fame by the United States United States, officially United States of America, republic (2005 est. pop. 295,734,000), 3,539,227 sq mi (9,166,598 sq km), North America. The United States is the world's third largest country in population and the fourth largest country in area.  Patent Office for his part in the discovery of sodium pentothal, one of the world's most widely used anesthetic agents. The new appointees bring total membership to 189.

A committee of Abbott's scientific leaders elects and promotes members of the society. Candidates are evaluated on their ingenuity, scientific excellence, consistent productivity and performance at Abbott. There are four levels of membership: associate research fellow, research fellow, senior research fellow and distinguished research fellow. A list of all new and promoted Volwiler Society members follows:
  Newly elected Volwiler Society members:

   Illinois                Bruce J. Dille, Ph.D.
   Massachusetts           Gerald R. Carson
   Ohio                    Chron-Si Lai, Ph.D.
   Ohio                    Alan S. Ryan, Ph.D.
   Germany                 Peter A. Noertersheuser, Ph.D.
   Illinois                James M. Trevillyan, Ph.D.
   Illinois                Yisheng Chen, Ph.D.
   Illinois                Gang Liu, Ph.D.
   Massachusetts           Tariq Ghayur, Ph.D.
   Illinois                Eric A. Schmitt, Ph.D.
   Illinois                Devalina Law, Ph.D.
   Illinois                Martin King, Ph.D.
   Illinois                Gin C. Hsieh, Ph.D.
   Illinois                Philip J. Hajduk, Ph.D.
   Illinois                Andrew M. Petros, Ph.D.
   Illinois                Robert A. Carr, Ph.D.
   Illinois                Sandeep Dutta, Ph.D.
   Massachusetts           Zehra Kaymakcalan, Ph.D.

  Promoted Volwiler Society members:
   Illinois                Jill E. Hochlowski, Ph.D.
   Illinois                Stephen W. Fesik, Ph.D.
   Illinois                M-Akhteruzzaman Molla, Ph.D.
   Illinois                George J. Dawson, Ph.D.
   Illinois                Arthur A. Hancock, Ph.D.
   Illinois                Dale J. Kempf, Ph.D.
   Illinois                Michael R. Michaelides, Ph.D.
   Illinois                Richard A. Rode, Ph.D.
   Illinois                Steven J. Wittenberger, Ph.D.
   Illinois                Hing L. Sham, Ph.D.

  Important HUMIRA Safety Information



Cases of tuberculosis (TB), frequently disseminated or extra pulmonary at clinical presentation, have been observed in patients receiving HUMIRA. Serious infections and sepsis, including fatalities, have been reported with the use of TNF-blocking agents, including HUMIRA.

Many of these infections occurred in patients on concomitant immunosuppressive therapy Immunosuppressive therapy
Medical treatment in which the immune system is purposefully thwarted. Such treatment is necessary, for example, to prevent organ rejection in transplant cases.
 that in addition to their underlying disease could predispose pre·dis·pose
v.
To make susceptible, as to a disease.
 them to infections. Other invasive opportunistic fungal infections have also been observed in patients treated with TNF-blocking agents, including HUMIRA.

TNF-blocking agents, including HUMIRA, have been associated in rare cases with exacerbation of demyelinating disease de·my·e·lin·at·ing disease
n.
Any of a group of diseases of unknown cause in which there is extensive loss of the myelin sheaths of nerve fibers, as in multiple sclerosis.
. The most frequent adverse events seen in the placebo-controlled clinical trials (HUMIRA vs. placebo) were injection site reactions (20 percent vs. 14 percent), upper respiratory infection Noun 1. upper respiratory infection - infection of the upper respiratory tract
respiratory infection, respiratory tract infection - any infection of the respiratory tract
 (17 percent vs. 13 percent), injection site pain (12 percent vs. 12 percent), headache (12 percent vs. 8 percent), rash (12 percent vs. 6 percent) and sinusitis sinusitis

Inflammation of the sinuses. Acute sinusitis, usually due to infections such as the common cold, causes localized pain and tenderness, nasal obstruction and discharge, and malaise.
 (11 percent vs. 9 percent). Discontinuations due to adverse events were 7 percent for HUMIRA and 4 percent for placebo. As with any treatment program, the benefits and risks of HUMIRA should be carefully considered before initiating therapy.

About Abbott Laboratories

Abbott Laboratories is a global, broad-based health care company devoted to the discovery, development, manufacture and marketing of pharmaceuticals, nutritionals, and medical products, including devices and diagnostics. The company employs more than 70,000 people and markets its products in more than 130 countries. In 2002, the company's sales were $17.7 billion.

Abbott's news releases and other information are available on the company's Web site at http://www.abbott.com/ .

CONTACT: Jennifer Smoter of Abbott Laboratories, +1-847-935-8865

Web site: http://www.abbott.com/

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Geographic Code:1USA
Date:Oct 29, 2003
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