ASPEED Announces ACCELLERANT for NONMEM; Speeds Response, Improves Accuracy of Non-Linear Regression Analysis Critical in Pharmaceutical & Life Sciences' Race-to-Market.NEW YORK New York, state, United States New York, Middle Atlantic state of the United States. It is bordered by Vermont, Massachusetts, Connecticut, and the Atlantic Ocean (E), New Jersey and Pennsylvania (S), Lakes Erie and Ontario and the Canadian province of -- ASPEED Software Corporation (www.aspeed.com) has announced the immediate availability of ACCELLERANT for NONMEM, the first solution that enables single-thread NONMEM applications to leverage the performance benefits of multiprocessor, multi-core, cluster, grid and other parallel distributed computing environments. Applying ASPEED's ACCELLERANT for NONMEM to long running analyses in several of the world's largest pharmaceutical companies has shown 2 to over 4 times run-time reductions, with equal or in some cases, even more precise results. This new software-based solution enhances the performance of the NONMEM software program for Nonlinear Mixed Effect Modeling applications, used by most pharmaceutical and bio-medical organizations to conduct more rapid and potentially comprehensive analysis during the drug development and approval process. The Population Pharmacokinetic/ Pharmacodynamic (PK/PD PK/PD Pharmacokinetic/Pharmacodynamic ) methods used are often very time consuming - with numerous long runs and significant complexity for researchers as they carve the analysis into pieces and subsequently aggregate the data to reduce the impact on the overall analysis elapsed time e·lapsed time n. The measured duration of an event. Noun 1. elapsed time - the time that elapses while some event is occurring . ACCELLERANT offers a big step to reducing time to market and competitiveness for pharmaceutical firms by decreasing individual run times of NONMEM and leveraging less expensive hardware platforms Each hardware platform, or CPU family, has a unique machine language. All software presented to the computer for execution must be in the binary coded machine language of that CPU. Following is a list of the major hardware platforms in existence today. See platform. . ACCELLERANT for NONMEM focuses on accelerating the non-linear regression analysis In statistics, a mathematical method of modeling the relationships among three or more variables. It is used to predict the value of one variable given the values of the others. For example, a model might estimate sales based on age and gender. used in the PK/PD. Unlike linear algorithms, NONMEM is not readily parallelized to exploit multi-processor, cluster or grid environments because of calculation data dependencies. Researchers can use ACCELLERANT's patent-pending technology to more rapidly achieve equal or more precise results without altering the integrity of the underlying logic or forcing NONMEM users to break up a run and manually combine the outputs. This ensures more comprehensive analysis and convergence for long running analysis. Once combined with NONMEM, ACCELLERANT software is completely transparent to application users and maintains the integrity and accuracy of all the existing NONMEM algorithms. This software solution requires no compiler changes and no parallel computing Solving a problem with multiple computers or computers made up of multiple processors. It is an umbrella term for a variety of architectures, including symmetric multiprocessing (SMP), clusters of SMP systems, massively parallel processors (MPPs) and grid computing. expertise, and can be applied to multi-processor/multi-core desktops as well as to local workgroups, clusters or grids. "NONMEM simulations are at the heart of most critical processes within the pharmaceutical and life sciences industries, where ensuring fast, accurate and affordable decision-making is a top-of-mind issue," said Kurt Ziegler, ASPEED's evp of product management. "ACCELLERANT for NONMEM responds to these challenges, allowing organizations to take full advantage of parallel and distributed computing (1) The use of multiple computers networked throughout a wide geographical area, or the world via the Internet, in order to solve a single problem. See grid computing. (2) The use of multiple computers in an enterprise rather than one centralized system. for run time reduction and improved precision - without the need for costly and time-consuming application changes." ACCELLERANT for NONMEM applies a simple automated update to the GloboMax(R) NONMEM product. Once ACCELLERANT for NONMEM has been integrated, the researcher simply needs to run the analysis as before and select the number of CPUs/Multi-cores to apply to the specific run. The update of NONMEM to include ACCELLERANT does not change the standard NONMEM logic. It runs the non-linear regression in parallel looking for Looking for In the context of general equities, this describing a buy interest in which a dealer is asked to offer stock, often involving a capital commitment. Antithesis of in touch with. convergence. ACCELLERANT for NONMEM's unique features include: --Full compatibility with Windows, Linux and Unix platforms using GCC GCC: see Gulf Cooperation Council. (compiler, programming) GCC - The GNU Compiler Collection, which currently contains front ends for C, C++, Objective-C, Fortran, Java, and Ada, as well as libraries for these languages (libstdc++, libgcj, etc). , Portland Group and Intel Optimized versions of FORTRAN --Advanced functionality that deploys the calculation to number of CPUs requested --Run transparently across the single/multi-core, multi-processor desktop systems, workgroup, Platform LSF LSF Lisofylline, see there or United Devices grid infrastructure --A one-time compile NONMEM update, which can be invoked as usual ACCELLERANT for NONMEM is available from ASPEED Software. It is licensed with an annual subscription fee based on the number of concurrently used CPUs. NONMEM licenses are available from GloboMax. About ASPEED Software ASPEED Software Corporation is a privately held, venture-funded software company based in the heart of New York City New York City: see New York, city. New York City City (pop., 2000: 8,008,278), southeastern New York, at the mouth of the Hudson River. The largest city in the U.S. with development centers in New York and London. ASPEED's value proposition is to enable clients with computationally intensive applications to significantly reduce response times and improves precision. ASPEED's ACCELLERANT software enables its users to quickly adapt their existing applications to use less expensive and newer hardware technologies in multi-processor, cluster and grid configurations. ACCELLERANT's algorithm-aware API enables the distribution of applications thought by many as "undistributable," improving competitiveness, productivity and accuracy of the analysis and to participate in company cluster and grid activity. For more information, please visit www.aspeed.com NONMEM is a registered trademark of The Regents of the University of California The Regents of the University of California make up the governing board of the University of California. The Board has 26 full (i.e., voting) members:
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