ALANEX announces drug discovery collaboration with ASTRA; second major collaboration for ALANEX in last 10 months.SAN DIEGO--(BUSINESS WIRE)--March 14, 1995--ALANEX Corp. Tuesday announced it has entered into a three-year drug discovery collaboration with ASTRA AB Astra AB is a former international pharmaceutical company based in Södertälje, Sweden. Astra was formed in 1913 and merged with the British Zeneca Group in 1999 to form AstraZeneca. of Stockholm, Sweden. The financial terms of the agreement were not disclosed. ALANEX will use its proprietary computational and molecular design technology, ALANET, to analyze ASTRA's chemical database to discover novel small molecule drugs for undisclosed targets, according to according to prep. 1. As stated or indicated by; on the authority of: according to historians. 2. In keeping with: according to instructions. 3. Marvin R. Brown, M.D., CEO (1) (Chief Executive Officer) The highest individual in command of an organization. Typically the president of the company, the CEO reports to the Chairman of the Board. of ALANEX. ``A key component of this collaboration, as well as our drug discovery programs as a whole, is ALANEX's Pharmacophore pharmacophore the group of atoms in the molecule of a drug responsible for the drug's action. Directed Parallel Synthesis (PDPS PDPS Professional Development Points PDPS Problem Driver Pointer System PDPS Product Definition Promotion System PDPS Power Distribution Panel for Slave (shelf) ) technology,'' said Brown. ``PDPS permits the rapid generation of diverse sets of organic structures around a pharmacophore derived from the ALANET analysis. This technology can be used for lead identification and in conjunction with traditional medicinal chemistry methods for lead optimization. PDPS includes both structure generation software to design novel molecules, and special equipment for the parallel synthesis of these molecules in large numbers.'' Dr. Martin Nicklasson, president of ASTRA ASTRA Ancient Instruments Sound/Timbre Reconstruction Application ASTRA Australian Strategic Air Traffic Management Group ASTRA Arab Supply and Trading Corporation ASTRA Automatic System for Transport Analysis ASTRA Automatic Satellite Tracking Research Antenna Pain Control said, ``This collaboration with ALANEX will enable us to enhance our existing drug discovery efforts. Through the use of ALANEX's computational approach to molecular design and diversity chemistry, we will focus both on optimizing our own leads as well as on the discovery of related compounds that exert a desirable therapeutic effect.'' In April 1994, ALANEX entered into a collaboration with Amgen Inc. to discover and develop small molecule drugs that act through peptide receptors for the treatment of certain neurological disorders. ASTRA is one of the fastest-growing pharmaceutical companies in the world, highly research-oriented and specialized in four areas: gastrointestinal, respiratory, cardiovascular and pain control. ASTRA's worldwide revenues in 1994 totaled $3.7 billion. ALANEX is a San Diego-based drug discovery company focused on developing non-peptide (``small molecule'') drugs that act through peptide receptors. The company has already discovered a new class of bioactive bi·o·ac·tive adj. Of or relating to a substance that has an effect on living tissue. bioactive having an effect on or eliciting a response from living tissue. compounds that may be used in the treatment of cardiovascular disease Cardiovascular disease Disease that affects the heart and blood vessels. Mentioned in: Lipoproteins Test cardiovascular disease and obesity. Design and synthesis, or proof of principle, of these new drugs was achieved by using ALANEX's novel molecular design system, ALANET. The company is also developing drugs for the treatment of stress-related diseases. CONTACT: ALANEX Laboratories Marvin R. Brown, 619/455-3200 or Keatinge & Associates Inc. Richard W. Keatinge, 619/625-2100 |
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