AIST and PharmaDesign Discovers a Prediction Method for Protein Disorder Area.Tokyo, Japan, Aug 14, 2006 - (JCN JCN Japan Corporate News JCN Journal of Cognitive Neuroscience JCN Journal of Cardiovascular Nursing JCN Journal of Christian Nursing JCN Job Control Number JCN Journal of Child Neurology JCN joint communications network (US DoD) ) - Advanced Industrial Science & Technology in collaboration with PharmaDesign Inc. have succeeded in finding a prediction method for Protein Disorder areas. Through this technique, improved efficiency of various experiments starting with conformation con·for·ma·tion n. One of the spatial arrangements of atoms in a molecule that can come about through free rotation of the atoms about a single chemical bond. analysis of proteins and X ray crystallography and NMR NMR: see magnetic resonance. will be possible. Having a conformation structure, Proteins function by interacting with other molecules based on its unique structure. The number of conformation analysis of proteins reached 30,000 up till now, and have consumed enormous energy and time. Recent study shows that disorder areas (areas where there is no specific conformation) are seen in transcription controlled proteins and proteins with DNA DNA: see nucleic acid. DNA or deoxyribonucleic acid One of two types of nucleic acid (the other is RNA); a complex organic compound found in all living cells and many viruses. It is the chemical substance of genes. . In addition, the disorder area is not prone to crystallization Crystallization The formation of a solid from a solution, melt, vapor, or a different solid phase. Crystallization from solution is an important industrial operation because of the large number of materials marketed as crystalline particles. and spectral assignment, therefore, analysis is easily done. PharmaDesign plans on using this prediction method for new drug discovery for its peptide library. Copyright [c] 2006 Japan Corporate News Network. All rights reserved. |
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