ADVISORY/National Colorectal Cancer Awareness Month 2003.

Business Editors/Health/Medical Writers

ADVISORY...for March

--(BUSINESS WIRE)

What:   NATIONAL COLORECTAL CANCER AWARENESS MONTH 2003

When:   March 2003

Who:    EXACT Sciences, a Massachusetts-based applied genomics
        company has developed a new non-invasive screening test for
        the early detection of colorectal cancer that will be
        commercially available in a few months. Colorectal cancer
        screening rates among adults aged 50 and older are
        surprisingly low and men and women of all ages need to
        understand that regular screening is the key to detecting and
        curing colorectal cancer. In fact, according to the American
        Cancer Society, survival rates for colorectal cancer are as
        high as 95 percent with early detection.

        The new test is called PreGen-Plus(TM) and will provide a more
        sensitive, completely non-invasive screening option.
        PreGen-Plus analyzes DNA extracted from a stool sample for
        abnormalities associated with colorectal cancer. The test will
        be ordered by physicians, and - in contrast to currently
        available screening methods - requires no special bowel
        preparation, stool handling or diet alterations, and samples
        can be collected in the privacy of one's own home. More
        importantly, PreGen-Plus is accurate in detecting actual
        disease. Multiple studies have demonstrated PreGen-Plus'
        ability to detect colorectal cancer at its earliest stages,
        with a low rate of false positives.

        PreGen-Plus holds immense promise as a first-line screening
        method from which people will not shy away. It is EXACT
        Sciences' belief that by removing some of the common barriers
        associated with current screening methods, more people will be
        screened for colorectal cancer and, thus, more lives will be
        saved.

        As the need to further educate the public during March and
        throughout the year on the importance of early screening for
        colorectal cancer is vital, we invite you to interview an
        EXACT Sciences representative, physician or patient for a
        story on screening. Please contact Amy Turner or Kate Jennings
        at the numbers below to arrange an interview or for more
        information on PreGen-Plus.