ADVISORY/March is National Colorectal Cancer Awareness Month.

Business Editors/Health/Medical Writers

ADVISORY...

--(BUSINESS WIRE)

New Non-Invasive, DNA-based

Colorectal Cancer Screening Option Available

Why:    This year, there is a new, innovative screening option
        available that you will want to take note of as you plan
        stories on colorectal cancer.

        PreGen-Plus(TM), one of the first commercial applications
        utilizing knowledge about the human genome, analyzes human DNA
        extracted from a stool sample for abnormalities associated
        with the presence of colorectal cancer. Unlike other screening
        methods, PreGen-Plus requires no special bowel preparation,
        stool handling or diet alterations.

        PreGen-Plus is designed to make colorectal cancer screening
        more comfortable and less intimidating. The test has only
        recently been introduced, but has already been successful in
        saving the lives of many people who had avoided screening
        because other options were viewed as uncomfortable, invasive
        or inaccurate.

Who:    EXACT Sciences, a Massachusetts-based applied genomics
        company, developed this new non-invasive screening test for
        the early detection of colorectal cancer. It is EXACT
        Sciences' belief that by removing some of the common barriers
        associated with current screening methods, more people will be
        screened for colorectal cancer and, thus, more lives will be
        saved.

        Facts About Colorectal Cancer:

        --  Approximately 150,000 new cases of colorectal cancer are
            diagnosed each year, resulting in approximately 57,000
            deaths annually.

        --  Ninety percent of all colorectal cancers occur in the 50+
            age group, which encompasses 80 million Americans.

        --  A recent study by the Partnership for Prevention showed
            that fewer than half of the population aged 50 and older
            receive any type of screening.

        --  Two-thirds of colorectal cancers are detected at a stage
            when the five-year survival rate is less than 50%. If
            colorectal cancer is detected at an early stage, survival
            rates approach 90%.

        --  Colorectal cancer can go undetected since it frequently is
            without symptoms until reaching a late, less curable
            stage. Symptoms of colorectal cancer, including blood in
            stool, are not always or consistently associated with the
            presence of the disease. DNA changes - which PreGen-Plus
            looks for - are the hallmark of EVERY cancer.

Contact:  Peggy Kochenbach                       Lauren Lampa
          617-267-8223 ext. 522                  617-267-8223 ext. 514
          [e-mail]                 [e-mail]

        For B-Roll or to arrange an interview with an EXACT Sciences
        representative contact Peggy Kochenbach or Lauren Lampa. We
        can also work with you to identify a physician and/or patient
        in your area that has experience with PreGen-Plus.

        B-Roll: Physician and Patient Exam* Colonoscope* Laboratory
        Footage* PreGen-Plus Footage* Soundbites with Physician,
        Colorectal Cancer Survivors and Patient Advocate* PreGen-Plus
        Animation