ADVISORY/Exploring the Applications of RNA Interference - RNAi - Technologies is the Focus of an Online Real-Time Virtual Seminar Presented by Genetic Engineering News.Health/Medical Writers ADVISORY...for Tuesday (July 15) BIOWIRE2K LARCHMONT, N.Y.--(BUSINESS WIRE)--June 17, 2003 Registrations are limited to ensure interactive participation Tuesday, July 15, 2003--Noon - 1:30 P.M. (E.S.T.) www.genseminars.com PRESENTED BY: Nassim Usman Ph.D. Chief Scientific Officer & Vice President of Research and Development Sirna Therapeutics MODERATED BY: Barry Polisky, Ph.D. Vice President of Research Sirna Therapeutics The process of RNA interference RNA interference n. A process in which the introduction of double-stranded RNA into a cell inhibits the expression of genes. (RNAi) mediated by small interfering RNA Small interfering RNA (siRNA), sometimes known as short interfering RNA or silencing RNA, are a class of 20-25 nucleotide-long double-stranded RNA molecules that play a variety of roles in biology. (siRNA) is proving to be of immense value in in vitro in vitro /in vi·tro/ (in ve´tro) [L.] within a glass; observable in a test tube; in an artificial environment. in vi·tro adj. In an artificial environment outside a living organism. gene silencing research. Many efforts are under way to extend the utility of siRNA into in vivo in vivo /in vi·vo/ (ve´vo) [L.] within the living body. in vi·vo adj. Within a living organism. in vivo adv. settings as a highly specific but more broadly applicable gene-silencing method. These efforts require chemical modifications to stabilize siRNA against nucleolytic degradation and mechanisms to optimize pharmacokinetic performance and delivery to target organs target organ n. A tissue or organ that is affected by a specific hormone. target organ, n the organ or body part whose activity levels demonstrate change in the course of biofeedback. . This online real-time presentation will focus on the applications of siRNA to identify and inhibit clinically relevant RNA RNA: see nucleic acid. RNA in full ribonucleic acid One of the two main types of nucleic acid (the other being DNA), which functions in cellular protein synthesis in all living cells and replaces DNA as the carrier of genetic targets. Emphasis will be placed on challenges involved in development of siRNAs as viable therapeutic agents in both systemic and local delivery settings.
THIS 90 MINUTE VIRTUAL SEMINAR WILL COVER:
-- Basic properties of the RNAi process
-- Aspects of RNAi gene silencing in selected systems in vitro
-- Recent applications of RNAi in vivo for antiviral and
endogenous gene silencing
-- Challenges associated with development of siRNAs as
therapeutic agents
TO REGISTER ONLINE GO TO:
www.genseminars.com
FOR FURTHER INFORMATION,PLEASE CONTACT:
Genetic Engineering News
GEN Virtual Seminars
2 Madison Ave.
Larchmont, NY 10538
(914) 834-3880
www.genseminars.com
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