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A recent study of antidepressant medication trials compared the drugs' published outcomes with all studies registered with the FDA.

A recent study of antidepressant medication trials compared the drugs' published outcomes with all studies registered with the FDA. The findings indicate that one-third (31%) of the registered studies were unpublished. Interestingly, studies with negative or questionable results (judged by FDA standards) were more likely to be either unpublished or, when published, to convey false and misleadingly positive outcomes. Publishing only positive results makes drugs appear to be more effective than they are, when both published and unpublished results are combined. For example, published literature on the anti-depressant drugs reviewed indicated that 94% of the trials had positive outcomes. Yet, the FDA analysis of all trials (published and unpublished studies) showed just 51% of trials had positive results. Such selective reporting and data manipulation poses great risks for potential adverse effects for consumers, study participants, and researchers.

The New England Journal of Medicine, JANUARY 17, 2008
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Title Annotation:WOMEN'S HEALTH SNAPSHOTS
Publication:Women's Health Activist
Date:Mar 1, 2008
Words:146
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