A new preservative for high pH systems: Rohm and Haas offers an alternative to formaldehyde in household and I&I applications.
FOR FORMULATORS OF household and I&I products, high pH formulations have typically been more difficult to preserve than low pH formulas. Many common preservatives preservatives,
n.pl food additives that hinder spoilage by reducing the growth of microorganisms. Include nitrates and nitrites, benzoates and sulfites, and many others. are less effective or less stable at alkaline pHs. (1) Rohm and Haas Rohm and Haas Company (NYSE: ROH), a Philadelphia, Pennsylvania based company, manufactures miscellaneous materials. A Fortune 500 Company, Rohm and Haas employs more than 17,000 people in 27 countries. The annual sales revenue of Rohm and Haas stands at about USD 8.2 billion. Company has addressed this issue by developing a technically innovative preservative preservative
Any of numerous chemical additives used to prevent or slow food spoilage caused by chemical changes (e.g., oxidation, mold growth) and maintain a fresh appearance and consistency. Antimycotics (e.g. that is specifically designed for use in hard-to-preserve, high pH formulations in household and I&I applications. Based on isothiazolinone chemistry, new Neolone M-10 preservative is a highly stable, safe and effective, broad-spectrum preservative that is particularly suitable as a replacement for formaldehyde formaldehyde (fôrmăl`dəhīd'), HCHO, the simplest aldehyde. It melts at −92°C;, boils at −21°C;, and is soluble in water, alcohol, and ether; at STP, it is a flammable, poisonous, colorless gas with a suffocating and formaldehyde donors in a wide range of applications, including liquid laundry products, all-purpose cleaners, furniture and floor care products and surfactants and other aqueous aqueous /aque·ous/ (a´kwe-us)
1. watery; prepared with water.
2. see under humor.
adj. raw materials.
The introduction of Neolone M-10 preservative reflects Rohm and Haas Company's position as one of the world's leading suppliers of preservative technology and its 30-year history as a developer of innovative products for applications in the household and I&I markets. In these applications, Neolone M-10 preservative complements Kathon CG/ICP preservative, which is most effective in less alkaline formulations.
Ncolone M-10 preservative is 9.5% methylisothiazolinone in water. It is miscible miscible /mis·ci·ble/ (mis´i-b'l) able to be mixed.
Capable of being and remaining mixed in all proportions. Used of liquids. in water, lower alcohols and glycols and has low solubility solubility
Degree to which a substance dissolves in a solvent to make a solution (usually expressed as grams of solute per litre of solvent). Solubility of one fluid (liquid or gas) in another may be complete (totally miscible; e.g. in hydrocarbons. The recommended use levels for Neolone M-10 preservative is 0.053-0.158% as supplied (50-150 ppm of active ingredient An active ingredient, also active pharmaceutical ingredient (or API), is the substance in a drug that is pharmaceutically active. Some medications may contain more than one active ingredient. ).
Neolone M-10 preservative shows excellent stability in household and I&I formulations with aqueous raw materials. Neolone M-10 preservative is stable over a wide range of pH and temperature conditions and is compatible with a variety of surfactants. The active ingredient is stable in surfactants and household products, such as laundry products, floor care products and all-purpose cleaners. The active ingredient was measured by high-performance liquid chromatography (HPLC HPLC high-performance liquid chromatography.
high performance liquid chromatography.
HPLC High-performance liquid chromatography Lab instrumentation A highly sensitive analytic method in which analytes are placed ) in a variety of household products and raw materials.
Figures 1-3 demonstrate these formulation advantages.
[FIGURE 1 OMITTED]
Neolone M-10 preservative exhibits strong antimicrobial antimicrobial /an·ti·mi·cro·bi·al/ (-mi-kro´be-al)
1. killing microorganisms or suppressing their multiplication or growth.
2. an agent with such effects. activity, inhibiting a wide range of Gram-positive and Gram-negative bacteria. Figure 4 provides the minimum inhibitory concentration minimum inhibitory concentration Lab medicine The minimum antibiotic concentration needed to inhibit bacterial growth from a clinical isolate–eg, a bloodborne infection, which is a form of antimicrobial susceptibility testing. Cf Minimum bactericidal concentration. (MIC) values in parts per" million active ingredient methylisothiazolinone, which inhibited the growth of various microorganisms in broth tests.
Long-term microbiological protection is obtained by employing use levels of up to 0.158% Neolone M-10 preservative as supplied. Typical use levels for most household and I&I products are in the range of 0.053% to 0.158% (50-150 ppm active ingredient). Efficacy of Neolone M-10 was evaluated in surfactants and household and I&I products using standard protocols. (2) Figures 5 and 6 illustrate that Neolone M-10 preservative is effective at low use levels in a variety of household and I&I products.
Bacterial and fungal efficacy of Neolone M-10 preservative was evaluated in sodium lauryl ethoxy eth·ox·y
The univalent radical C2H5O.
Relating to or containing the ethoxy radical. sulfate sulfate, chemical compound containing the sulfate (SO4) radical. Sulfates are salts or esters of sulfuric acid, H2SO4, formed by replacing one or both of the hydrogens with a metal (e.g., sodium) or a radical (e.g., ammonium or ethyl). (Figure 5) and a liquid laundry detergent (Figure 6). Samples were inoculated with [10.sup.6] to [10.sup.7] organisms/g and monitored for viable microorganisms at appropriate time intervals using standard plating methods. Bacterial samples were stored at 30[degrees]C and fungal samples at 25[degrees]C for the duration of the test. The preservative was deemed effective if no microorganisms survived in the samples.
Test results shown in Figures 5 and 6 clearly demonstrate that Neolone M-10 preservative is effective at low use levels in household and l&I products.
Neolone M-10 preservative is recognized as being extremely safe for the environment. It has low use levels, rapidly biodegrades to non-toxic substances, does not persist in Verb 1. persist in - do something repeatedly and showing no intention to stop; "We continued our research into the cause of the illness"; "The landlord persists in asking us to move"
continue the environment and is halogen-free. In addition, Neolone M-10 preservative does not affect the performance of waste-water treatment plants and does not bioaccumulate. Also, the predicted environmental concentration (PEC Peć (pĕch), Albanian Peja, town (1991 pop. 68,163), S Serbia, in the Kosovo region. A trade center, it has industries that produce leather goods, foodstuffs, and handicrafts. ) of Neolone M-10 preservative will be significantly less than the toxic threshold, and thus will have minimal environmental impact.
The toxicology of methylisothiazolinone, the active ingredient of Neolone M-10 preservative, has been assessed in an extensive battery of non-clinical and clinical testing. Results of these studies prove that Neolone M-10 preservative does not present a mutagenic mutagenic
inducing genetic mutation. , teratogenic ter·a·to·gen·ic
Of, relating to, or causing malformations of an embryo or a fetus.
pertaining to or emanating from teratogen. , reproductive or carcinogenic carcinogenic
having a capacity for carcinogenesis. risk to humans. Use of Neolone M-10 preservative at recommended use levels is safe. This is supported by our" extensive toxicological and clinical databases, our work with dermatologists worldwide and more than 20 years of experience with safe use of isothiazolinone chemistry in a large number of household and I&I products around the world.
A Formaldehyde-Free Solution
Today's preservatives are formulated in household and I&I products principally to protect them from chance microbial microbial
pertaining to or emanating from a microbe.
the breakdown of organic material, especially feedstuffs, by microbial organisms. contamination during production, storage and final customer use. High pH formulations of these products are frequently difficult to preserve. Neolone M-10 preservative--stable over a range of pH and temperatures, highly effective and safe--provides formulators of household and I&I products with a proven formaldehyde-free solution for high pH formulations.
For additional information on new Neolone M-10 preservative, visit http://www.rhcis.com.
Kathon and Neolone are registered trademarks of Rohm and Haas Company.
Fig. 2: Neolone M-10 preservative is stable in surfactants % Active Ingredient (AI) Remaining at Four Weeks: Matrix 25[degrees]C 42[degrees]C 50[degrees]C Sodium alkyl benzene sulfate 100 100 Not Tested Sodium lauryl ethoxy sulfate 100 100 100 Sodium [C.sub.14-16] olefin sulfonate 100 93 79 Sodium lauryl sulfate 100 100 100 Sodium lauroyl sarcosinate 84 (52 weeks at 25[degrees]C) Fig. 3: Neolone M-10 preservative is stable in household and I&I products Temperature Time % AI Matrix pH [degrees]C Weeks Remaining Laundry Products Fabric wash concentrate 8 45 4 96 Laundry detergent 9 25 12 80 Floor Care Products Floor finish 9 45 4 90 Floor polish 8 40 12 100 Liquid Cleaners Shower cleaner 9 40 12 100 Dish detergent 8 40 12 100 Scrub product 8 40 12 100 Fig. 4. Neolone M-10 preservative inhibits a range of bacteria at low levels MIC Microorganism ATCC # ppm AI Enterobacter aerogenes 15038 30 Pseudomonas aeruginosa 15442 40 Burkholderia cepacia 17765 20 Pseudomonas oleovorans 8062 30 Pseudomonas putida 795 20 Staphylococcus aureus 6538 40 Serratia marcescens Isolate 30 Test parameters: Nutrient Broth, 30[degrees]C / pH 7; 24-hour contact time Fig. 5: Neolone M-10 preservative efficacy in Concentration CFU/g after day: Preservative % AI 7 14 28 Bacteria U11preserved 0 [10.sup.8] [10.sup.7] [10.sup.7] Neolone M-10 0.0050 <10 <10 <10 Fungi Unpreserved 0 [10.sup.7] [10.sup.7] [10.sup.7] Neolone M-10 0.0050 <10 <10 <10 Fig. 6: Neolone M-10 preservative efficacy in a liquid laundry detergent Concentration CFU/g after day: Preservative % AI 7 14 28 Bacteria Unpreserved 0 [10.sup.6] [10.sup.6] [10.sup.6] Neolone M-10 0.0050 <10 <10 <10 Fungi Unpreserved 0 [10.sup.6] [10.sup.6] [10.sup.6] Neolone M-10 0.0075 <10 <10 <10
(1.) Steinberg, D.C. 1996. Preservatives for Cosmetics. Cosmetics and Toiletries toi·let·ry
n. pl. toi·let·ries
An article, such as toothpaste or a hairbrush, used in personal grooming or dressing.
toiletries npl → artículos mpl de aseo (= .
(2.) Curry, Anita S, Joyce F. Graf, and G. N. McEwen Jr., eds. 1993. Determining the Preservative Adequacy in Cosmetic Formulations. CTFA CTFA Cosmetic, Toiletry, and Fragrance Association
CTFA Certified Trust and Financial Advisor
CTFA Canadian Table of Frequency Allocations
CTFA Certificate in Teaching French to Adults Microbiology Guidelines.
Megan A. Diehl Applications Scientist, Preservatives Consumer & Industrial Specialties Business Rohm and Haas Company