A new preservative for high pH systems: Rohm and Haas offers an alternative to formaldehyde in household and I&I applications.
The introduction of Neolone M-10 preservative reflects Rohm and Haas Company's position as one of the world's leading suppliers of preservative technology and its 30-year history as a developer of innovative products for applications in the household and I&I markets. In these applications, Neolone M-10 preservative complements Kathon CG/ICP preservative, which is most effective in less alkaline formulations.
Ncolone M-10 preservative is 9.5% methylisothiazolinone in water. It is miscible in water, lower alcohols and glycols and has low solubility in hydrocarbons. The recommended use levels for Neolone M-10 preservative is 0.053-0.158% as supplied (50-150 ppm of active ingredient).
Neolone M-10 preservative shows excellent stability in household and I&I formulations with aqueous raw materials. Neolone M-10 preservative is stable over a wide range of pH and temperature conditions and is compatible with a variety of surfactants. The active ingredient is stable in surfactants and household products, such as laundry products, floor care products and all-purpose cleaners. The active ingredient was measured by high-performance liquid chromatography (HPLC) in a variety of household products and raw materials.
Figures 1-3 demonstrate these formulation advantages.
[FIGURE 1 OMITTED]
Neolone M-10 preservative exhibits strong antimicrobial activity, inhibiting a wide range of Gram-positive and Gram-negative bacteria. Figure 4 provides the minimum inhibitory concentration (MIC) values in parts per" million active ingredient methylisothiazolinone, which inhibited the growth of various microorganisms in broth tests.
Long-term microbiological protection is obtained by employing use levels of up to 0.158% Neolone M-10 preservative as supplied. Typical use levels for most household and I&I products are in the range of 0.053% to 0.158% (50-150 ppm active ingredient). Efficacy of Neolone M-10 was evaluated in surfactants and household and I&I products using standard protocols. (2) Figures 5 and 6 illustrate that Neolone M-10 preservative is effective at low use levels in a variety of household and I&I products.
Bacterial and fungal efficacy of Neolone M-10 preservative was evaluated in sodium lauryl ethoxy sulfate (Figure 5) and a liquid laundry detergent (Figure 6). Samples were inoculated with [10.sup.6] to [10.sup.7] organisms/g and monitored for viable microorganisms at appropriate time intervals using standard plating methods. Bacterial samples were stored at 30[degrees]C and fungal samples at 25[degrees]C for the duration of the test. The preservative was deemed effective if no microorganisms survived in the samples.
Test results shown in Figures 5 and 6 clearly demonstrate that Neolone M-10 preservative is effective at low use levels in household and l&I products.
Neolone M-10 preservative is recognized as being extremely safe for the environment. It has low use levels, rapidly biodegrades to non-toxic substances, does not persist in the environment and is halogen-free. In addition, Neolone M-10 preservative does not affect the performance of waste-water treatment plants and does not bioaccumulate. Also, the predicted environmental concentration (PEC) of Neolone M-10 preservative will be significantly less than the toxic threshold, and thus will have minimal environmental impact.
The toxicology of methylisothiazolinone, the active ingredient of Neolone M-10 preservative, has been assessed in an extensive battery of non-clinical and clinical testing. Results of these studies prove that Neolone M-10 preservative does not present a mutagenic, teratogenic, reproductive or carcinogenic risk to humans. Use of Neolone M-10 preservative at recommended use levels is safe. This is supported by our" extensive toxicological and clinical databases, our work with dermatologists worldwide and more than 20 years of experience with safe use of isothiazolinone chemistry in a large number of household and I&I products around the world.
A Formaldehyde-Free Solution
Today's preservatives are formulated in household and I&I products principally to protect them from chance microbial contamination during production, storage and final customer use. High pH formulations of these products are frequently difficult to preserve. Neolone M-10 preservative--stable over a range of pH and temperatures, highly effective and safe--provides formulators of household and I&I products with a proven formaldehyde-free solution for high pH formulations.
For additional information on new Neolone M-10 preservative, visit http://www.rhcis.com.
Kathon and Neolone are registered trademarks of Rohm and Haas Company.
Fig. 2: Neolone M-10 preservative is stable in surfactants % Active Ingredient (AI) Remaining at Four Weeks: Matrix 25[degrees]C 42[degrees]C 50[degrees]C Sodium alkyl benzene sulfate 100 100 Not Tested Sodium lauryl ethoxy sulfate 100 100 100 Sodium [C.sub.14-16] olefin sulfonate 100 93 79 Sodium lauryl sulfate 100 100 100 Sodium lauroyl sarcosinate 84 (52 weeks at 25[degrees]C) Fig. 3: Neolone M-10 preservative is stable in household and I&I products Temperature Time % AI Matrix pH [degrees]C Weeks Remaining Laundry Products Fabric wash concentrate 8 45 4 96 Laundry detergent 9 25 12 80 Floor Care Products Floor finish 9 45 4 90 Floor polish 8 40 12 100 Liquid Cleaners Shower cleaner 9 40 12 100 Dish detergent 8 40 12 100 Scrub product 8 40 12 100 Fig. 4. Neolone M-10 preservative inhibits a range of bacteria at low levels MIC Microorganism ATCC # ppm AI Enterobacter aerogenes 15038 30 Pseudomonas aeruginosa 15442 40 Burkholderia cepacia 17765 20 Pseudomonas oleovorans 8062 30 Pseudomonas putida 795 20 Staphylococcus aureus 6538 40 Serratia marcescens Isolate 30 Test parameters: Nutrient Broth, 30[degrees]C / pH 7; 24-hour contact time Fig. 5: Neolone M-10 preservative efficacy in Concentration CFU/g after day: Preservative % AI 7 14 28 Bacteria U11preserved 0 [10.sup.8] [10.sup.7] [10.sup.7] Neolone M-10 0.0050 <10 <10 <10 Fungi Unpreserved 0 [10.sup.7] [10.sup.7] [10.sup.7] Neolone M-10 0.0050 <10 <10 <10 Fig. 6: Neolone M-10 preservative efficacy in a liquid laundry detergent Concentration CFU/g after day: Preservative % AI 7 14 28 Bacteria Unpreserved 0 [10.sup.6] [10.sup.6] [10.sup.6] Neolone M-10 0.0050 <10 <10 <10 Fungi Unpreserved 0 [10.sup.6] [10.sup.6] [10.sup.6] Neolone M-10 0.0075 <10 <10 <10
(1.) Steinberg, D.C. 1996. Preservatives for Cosmetics. Cosmetics and Toiletries.
(2.) Curry, Anita S, Joyce F. Graf, and G. N. McEwen Jr., eds. 1993. Determining the Preservative Adequacy in Cosmetic Formulations. CTFA Microbiology Guidelines.
Megan A. Diehl Applications Scientist, Preservatives Consumer & Industrial Specialties Business Rohm and Haas Company
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|Author:||Diehl, Megan A.|
|Publication:||Household & Personal Products Industry|
|Date:||Aug 1, 2002|
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