2008 Edition of the Leukemia Drug Pipeline Update Examines the Latest Developments in the Sector.DUBLIN, Ireland -- Research and Markets (http://www.researchandmarkets.com/reportinfo.asp?report_id=356342) has announced the addition of Leukemia Drug Pipeline Update 2008 to their offering. Leukemia includes a broad variety of histological separate disorders which make the leukemia market segmented. There are today more than 240 therapeutics targeting leukemia, from early preclinical to marketed drugs. Leukemia Drug Pipeline Update lists all drugs and gives you a progress analysis on each one of them. Identified drugs are linked to 132 different targets. These targets are further categorized on the CD-ROM CD-ROM: see compact disc. CD-ROM in full compact disc read-only memory Type of computer storage medium that is read optically (e.g., by a laser). by 46 classifications of molecular function and with pathway referals to BioCarta, KEGG and NetPath. Read more below on how the Leukemia Drug Pipeline Update is organized. How May Drug Pipeline Update Be of Use? Show investors/board/management that you are right on top of drug development progress in your therapeutic area. Find competitors, collaborations partners, M&A candidates etc. Jump start competitive drug intelligence operations Excellent starting point for world wide benchmarking Compare portfolio and therapy focus with your peers Speed up pro-active in-/out licensing strategy work Fast and easy way of tracking drugs using search engines; just one click from inside the application and you may search the World Wide Web and PubMed for any drug. Drug Pipeline Update is delivered to you as a CD-ROM application, which requires no installation on your computer. Please read more about application features and system requirements below. Drug Pipeline Update at a Glance Investigators Includes more than 170 principal investigators plus their collaborators. There is direct access from inside the application to web pages of all principal investigators. Note: You are able to sort and find drugs according to investigators and partners from drop-down menus in the application. You may also sort and find drugs according to country of investigator. Drug name & Synonyms Lists commercial, generic and code names for drugs. In all more than 350 names Developmental stage This Drug Pipeline Update contains more than 240 drugs in active development for the treatment of leukemia (including: ALL, AML, CLL, CML and HCL) 49 marketed drugs - 15 projects in Phase III - 90 projects in Phase II - 85 projects in Phase I - 50 projects in Preclinical Targets Identified drugs are linked to more than 132 different targets, divided into 46 classifications of molecular function: - Carboxy-lyase activity - Catalytic activity - Cell adhesion molecule activity - Chaperone chaperone /chap·er·one/ (shap´er-on) someone or something that accompanies and oversees another. molecular chaperone activity - Cysteine-type peptidase activity - Cytokine activity - Deaminase deaminase /de·am·i·nase/ (de-am´i-nas) an enzyme causing deamination, or removal of the amino group from organic compounds, usually cyclic amidines. de·am·i·nase n. activity - DNA binding - DNA repair protein - DNA topoisomerase activity - DNA-directed DNA polymerase activity - DNA-methyltransferase activity - G-protein coupled receptor activity - Growth factor activity - Hydrolase hydrolase /hy·dro·lase/ (hi´dro-las) one of the six main classes of enzymes, comprising those that catalyze the hydrolytic cleavage of a compound. hy·dro·lase n. activity - Kinase activity - Kinase regulator activity - Ligand-dependent nuclear receptor activity - Ligase ligase /li·gase/ (li´gas) (lig´as) any of a class of enzymes that catalyze the joining together of two molecules coupled with the breakdown of a pyrophosphate bond in ATP or a similar triphosphate. activity - Lipid phosphatase activity - MHC class I receptor activity - Molecular function unknown - Motor activity - Oxidoreductase oxidoreductase /ox·i·do·re·duc·tase/ (ok?si-do-re-duk´tas) any of a class of enzymes that catalyze the reversible transfer of electrons from a substrate that becomes oxidized to one that becomes reduced (oxidation-reduction, or redox activity - Phosphoric phos·phor·ic adj. Of, relating to, or containing phosphorus, especially with a valence of 5 or a valence higher than that of a comparable phosphorous compound. diester hydrolase activity - Phosphorylase phosphorylase /phos·phor·y·lase/ (fos-for´i-las) 1. any of a group of enzymes that catalyze the phosphorolysis of glycosides, transferring the cleaved glycosyl group to inorganic phosphate. activity - Protein binding - Protein serine/threonine kinase activity - Protein tyrosine phosphatase activity - Protein-tyrosine kinase activity - Receptor activity - Receptor binding - Receptor signaling complex scaffold activity - RNA binding - RNA-directed DNA polymerase activity - Serine-type peptidase activity - Structural constituent of cytoskeleton cytoskeleton System of microscopic filaments or fibres, present in the cytoplasm of eukaryotic cells (see eukaryote), that organizes other cell components, maintains cell shape, and is responsible for cell locomotion and for movement of the organelles within it. - Superoxide dismutase activity - T cell receptor activity - Transcription factor activity - Transcription regulator activity - Transferase activity - Translation regulator activity - Transmembrane receptor activity - Transmembrane receptor protein tyrosine kinase activity - Transporter activity Identified targets are categorized into 21 different primary and alternate sub-cellular localizations: - Cell surface - Centrosome - Clathrin-coated vesicle - Cytoplasm - Cytoplasmic vesicle - Cytoskeleton - Cytosol cytosol /cy·to·sol/ (sit´ah-sol) the liquid medium of the cytoplasm, i.e., cytoplasm minus organelles and nonmembranous insoluble components.cytosol´ic cy·to·sol n. - Endoplasmic endoplasmic pertaining to or arising from endoplasm. endoplasmic ribosomes small, cytoplasmic granules consisting of approximately 60% RNA and 40% protein. reticulum - Endosome - Extracellular - Golgi apparatus - Lysosome lysosome Membrane-enclosed organelle found in all eukaryotic cells (see eukaryote) that is responsible for the cell's digestion of macromolecules, old cell parts, and microorganisms. - Mitochondrial mitochondrial pertaining to mitochondria. mitochondrial RNAs a unique set of tRNAs, mRNAs, rRNAs, transcribed from mitochondrial DNA by a mitochondrial-specific RNA polymerase, that account for about 4% of the total cell RNA that membrane - Mitochondrion - Nuclear membrane - Nucleolus nucleolus: see cell. - Nucleus - Perinuclear perinuclear /peri·nu·cle·ar/ (-noo´kle-ar) near or around a nucleus. region - Perinuclear vesicle - Peroxisome Peroxisome An intracellular organelle found in all eukaryotes except the archezoa (original lifeforms). In electron micrographs, peroxisomes appear round with a diameter of 0.1–1. Application Features Use 13 different parameters, available in drop-down menus, to find and sort among drugs - Drug status - Clinical Trial Status - Principle Investigator - Partners - Indication - Developmental Stage - Compound Type - Mechanism - Target - Molecular Function of Target - Target Localization - Targeted Pathways - Free text search of entire drug profile contents Direct linkage from inside the application to related internet resources - Drug data is linked to search engines like Google and PubMed - Drug target data is linked directly to BioCarta, Human Protein Atlas, KEGG, and NetPath - Direct links to company web pages of principal investigators For more information visit http://www.researchandmarkets.com/reportinfo.asp?report_id=356342 |
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