'X-Ray Crystallography of Biomacromolecules' Covers the Theory, Practice and Latest Achievements in X-Ray Crystallography.DUBLIN, Ireland -- Research and Markets (http://www.researchandmarkets.com/reports/c52134) has announced the addition of X-Ray Crystallography X-ray crystallography, the study of crystal structures through X-ray diffraction techniques. When an X-ray beam bombards a crystalline lattice in a given orientation, the beam is scattered in a definite manner characterized by the atomic structure of the lattice. of Biomacromolecules: A Practical Guide to their offering. Written by one of the most significant contributors to the progress of protein crystallography, this practical guide contains case studies, a troubleshooting section and pointers on data interpretation. It covers the theory, practice and latest achievements in x-ray crystallography, such that any researcher in structural biology Structural biology is a branch of molecular biology concerned with the study of the architecture and shape of biological macromolecules—proteins and nucleic acids in particular—and what causes them to have the structures they have. will benefit from this extremely clearly written book. Part A covers the theoretical basis and such experimental techniques Experimental research designs are used for the controlled testing of causal processes. The general procedure is one or more independent variables are manipulated to determine their effect on a dependent variable. as principles of x-ray diffraction, solutions for the phase problem and time-resolved x-ray crystallography. Part B includes case studies for different kinds of x-ray crystal structure determination, such as the MIRAS MIRAS Mortgage Interest Relief At Source MIRAS Mobile Interactive Remote Activated Solutions MIRAS Mobile Interactive Remote Activated System and MAD techniques, molecular replacement, and the difference Fourier technique. About the Author Albrecht Messerschmidt is head of a research group at Max-Planck-Institute for Biochemistry in Martinsried, Germany, department of proteomics and signal transduction Signal transduction The transmission of molecular signals from a cell's exterior to its interior. Molecular signals are transmitted between cells by the secretion of hormones and other chemical factors, which are then picked up by different cells. headed by Matthias Mann Matthias Mann (born 1959) is a scientist in the area of mass spectrometry and proteomics. Born 1959 in Germany he studied mathematics and physics at the University of Goettingen. He received his Ph.D. . He gained his Ph.D. in Crystallography at the Humboldt University in Berlin under Bill Kleber. After working on the X-ray crystallography of small biological molecules he moved to the field of X-ray crystallography of biomacromolecules, working in the department of structural research under Nobel laureate Noun 1. Nobel Laureate - winner of a Nobel prize Nobelist laureate - someone honored for great achievements; figuratively someone crowned with a laurel wreath Robert Huber For the U.S. Representative from Michigan, see Robert J. Huber. Robert Huber is a German biochemist and Nobel laureate. He was born 20 February 1937 in Munich where his father, Sebastian, was a bank cashier. . He gained his lecturing qualification in the field of physical biochemistry at the faculty of biology of the University of Constance in 1996, where he was appointed extraordinary professor in 2002. The author has published great number of scientific papers and is one of the editors of the three volume Handbook of Metalloproteins. Content Outline: Preface. Part I Principles and Methods. 1 Introduction. 2 Experimental Techniques. 3 Principles of X-Ray Diffraction by a Crystal. 4 Diffraction Data Evaluation. 5 Methods for Solving the Phase Problem. 6 Phase Improvement by Density Modification and Phase Combination. 7 Model Building and Refinement. 8 Crystal Structure Determination of the Time-Course of Reactions and of Unstable Species. 9 Structural Genomics. Part II Practical Examples. Introductory Remarks. 10 Data Evaluation. 11 Determination of Anomalous Scatterer or Heavy Atom Positions. 12 MIRAS and MAD Phasing with the Program SHARP. 13 Molecular Replacement. 14 Averaging about Non-Crystallographic Symmetry (NCS (Network Call Signaling) CableLabs version of MGCP. See MGCP/MEGACO. NCS - Network Computing System: Apollo's RPC system used by DEC and Hewlett-Packard.The protocol has been adopted by OSF. ) for 4-BUDH. 15 Model Building and More. References. Subject Index. For more information visit http://www.researchandmarkets.com/reports/c52134 |
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