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'Pied piper' molecule key in treating prostate cancer, leukemia.


Byline: ANI

Washington, Apr 29 (ANI): Scientists from Western Australian Institute for Medical Research (WAIMR WAIMR Western Australian Institute for Medical Research ) have identified what they called a 'Pied Piper' molecule that can offer a key in treating prostate prostate /pros·tate/ (pros´tat) a gland surrounding the bladder neck and urethra in the male; it contributes a secretion to the semen.prostat´ic

pros·tate
n.
The prostate gland.

adj.
, breast and colon cancers colon cancer, cancer of any part of the colon (often called the large intestine). Colon cancer is the second most common cancer diagnosed in the United States.  as well as leukemia leukemia (lkē`mēə), cancerous disorder of the blood-forming tissues (bone marrow, lymphatics, liver, spleen) characterized by excessive production of immature or mature .

The molecule within blood cells blood cells,
n.pl the formed elements of the blood, including red cells (erythrocytes), white cells (leukocytes), and platelets (thrombocytes).


blood cells

See erythrocyte and leukocyte. Platelets are classed separately.
, called Liar Liar - MIT Scheme , leads other molecules into the nucleus of the cell.

Associate Professor Ingley said the findings were a leap forward in the understanding of how blood cells develop and divide, which could offer them a key to turning off cancerous cell growth.

"Liar is like a key, which opens a pathway into the nucleus of a blood cell for a number of other molecules, allowing them to flow in - and these molecules are what signal the cell to develop and divide," he said.

"From here, if we could control Liar, the hope is that we could use it to switch off the growth of abnormal, or cancerous, cells.

"Because Liar is present in every blood cell, this knowledge could help treat a huge range of conditions and diseases, but where it has most potential is in cancers of the prostate, breast, colon and blood where activity of the enzyme Lyn is heightened," he added

The cellular enzyme Lyn acts as a switch that 'turns on' blood cell development.

"We could see Lyn had a big influence on blood cell development, so to understand how it works, we looked at what it interacts with and the effects it has," said Professor Ingley.

"What we then saw was Lyn interacting with Liar, and noticed it also interacted with other molecules that signal the cell to behave a certain way.

"Now we have identified Liar and Lyn and we know what they do, we'll be looking at them more closely to find out how they may have the potential to help treat cancers," he added.

The study appears in journal Blood. (ANI)

Copyright 2009 Asian News International The Asian News International (ANI) agency provides multimedia news to China and 50 bureaus in India. It covers virtually all of South Asia since its foundation and presently claims, on its official website, to be the leading South Asia-wide news agency.  (ANI) - All Rights Reserved.

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Publication:Asian News International
Date:Apr 29, 2009
Words:332
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