[Translation of front cover text] Use of Vaccine Has Spread from Osaka to Edo (Tokyo) for the Benefit of Mankind.

I wonder who in the world named Smallpox a God? It is no more than a demon that deviated from the path of mankind.

There are approximately five ways of treating smallpox; one is called the vaccinia method. In the 1790s, a Dutchman [sic] named Edward Jenner announced this method. It is said that when this method was first used, a vaccine made from cow's blood was directly injected into patients. It was quite astonishing that this vaccine, which was made from blood drawn from cow udders and was used on children, cured smallpox.

The first form of this vaccine was the Dutch form, but the Chinese form was used after 1806. The Chinese form is currently being used in Japan, but many forms and methods are used throughout the world. In this manner, vaccination has become a method of treating smallpox.

We began using the Dutch form of the vaccine in the latter half of the 1800s. Thanks to the patronage of our loyal customers, the use of our vaccine has spread widely.

(Translator's note: At the end of this advertisement, there is a poem, the gist of which is, "Parents should do whatever they can to ensure the well-being of their children.")