'Zinc zipper' key to antibiotic-resistant hospital-acquired infections.Byline: ANI Washington, December 5 (ANI): Researchers at the University of Cincinnati The University of Cincinnati is a coeducational public research university in Cincinnati, Ohio. Ranked as one of America’s top 25 public research universities and in the top 50 of all American research universities,[2] (UC) in America have found that zinc plays a key role in hospital-acquired infections, which are resistant to traditional antibiotic treatment. The researchers say that the presence of zinc is crucial to the formation of infection-causing biofilms. About two-thirds of all hospital-acquired infections can be traced to two staphylococcal staphylococcal pertaining to Staphylococcus spp. staphylococcal clumping test used as a means of measuring the quantity of fibrinogen-split products in a sample of blood. species, Staphylococcus aureus and Staphylococcus epidermidis, according to background information in an article published in the online edition of Proceedings of the National Academy of Sciences The Proceedings of the National Academy of Sciences of the United States of America, usually referred to as PNAS, is the official journal of the United States National Academy of Sciences. . Staphylococci can grow as biofilms, which are specialized communities of bacteria that are highly resistant to antibiotics and immune responses. Since they are highly adhesive, they can grow on many surfaces, including implanted medical devices like pacemakers, heart valve replacements and artificial joints. The UC researchers say that incidences of staph infections can be significantly reduced by inhibiting the growth of such biofilms. Dr. Andrew Herr, an assistant professor and Ohio Eminent Scholar in structural biology, has discovered that zinc enables a protein on the bacterial surface to act like molecular Velcro, allowing the bacterial cells to stick to one another. He also observed that the removal of zinc using an organic compound called diethylenetriamine pentaacetic acid diethylenetriamine pentaacetic acid /di·eth·yl·ene·tri·amine pen·ta·ace·tic ac·id/ (DTPA) (-en-tri´ah-men pen?tah-ah-se´tik) pentetic acid. di·eth·yl·ene·tri·a·mine pen·ta·a·ce·tic acid n. (DTPA DTPA diethylenetriamine pentaacetic acid; see pentetic acid. DTPA diethylenetriamine penta-acetic acid. ) prevented biofilm Biofilm An adhesive substance, the glycocalyx, and the bacterial community which it envelops at the interface of a liquid and a surface. When a liquid is in contact with an inert surface, any bacteria within the liquid are attracted to the surface and adhere formation by Staphylococcus epidermidis and Staphylococcus aureus. "We've shown that if you remove the zinc, you prevent the biofilm from forming, and if you add zinc back, the biofilm can grow. So we're hopeful that we can use this sort of approach to prevent these biofilms from ever taking hold in the first place," he says. Given that zinc activates immune cells and plays many other important roles in the body, the researchers deem it impractical to use an intravenous injection to remove it, for it may disturb its balance. Herr says that his lab will continue searching for a way to overcome this problem. (ANI) Copyright 2008 Asian News International The Asian News International (ANI) agency provides multimedia news to China and 50 bureaus in India. It covers virtually all of South Asia since its foundation and presently claims, on its official website, to be the leading South Asia-wide news agency. (ANI) - All Rights Reserved. Provided by Syndigate.info an Albawaba.com company |
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