$20 Million Gift from Arnold and Mabel Beckman Foundation Establishes New Model for Cancer Immunotherapy.DUARTE, Calif. -- Arnold and Mabel Beckman Center for Cancer Immunotherapeutics and Tumor Immunology to Advance Innovative Research at City of Hope Cancer Center
City of Hope Cancer Center has received a $20 million grant from the Arnold and Mabel Beckman Foundation. The naming gift will establish the Arnold and Mabel Beckman Center for Cancer Immunotherapeutics and Tumor Immunology, an innovative research center dedicated to immunotherapy, a treatment that uses the immune system immune system
Cells, cell products, organs, and structures of the body involved in the detection and destruction of foreign invaders, such as bacteria, viruses, and cancer cells. Immunity is based on the system's ability to launch a defense against such invaders. to fight cancer and other diseases.
Of the $20 million gift, $15 million is a match of an anonymous donor's gift, while $5 million is a challenge grant to be matched by new donations.
The Arnold and Mabel Beckman Foundation grant accelerates City of Hope's efforts to build a fully integrated research facility that will house scientists focused on tumor immunology and translational research, the conversion of basic science discoveries into novel diagnostic methods and treatments for patients.
The Arnold and Mabel Beckman Center will provide space and resources for scientists in City of Hope's Division of Cancer Immunotherapeutics & Tumor Immunology (CITI CITI Columbia Institute for Tele-Information (Columbia University)
CITI Center for Information Technology Integration (University of Michigan)
CITI Collaborative IRB Training Initiative ). Within the center, scientists will research new treatment ideas, manufacture biologic agents on site and conduct preclinical testing and clinical trials.
"This generous and visionary gift will help enable major advances in the development of new and improved therapies for patients with cancer," said Michael A. Friedman, M.D., president and chief executive officer, City of Hope. "The creation of the Arnold and Mabel Beckman Center for Cancer Immunotherapeutics and Tumor Immunology demonstrates commitment by both the Arnold and Mabel Beckman Foundation and City of Hope to play a key role in an emerging field that holds great promise for patients facing life-threatening diseases."
"The Arnold and Mabel Beckman Foundation is pleased to be able to continue our support of City of Hope and the new Arnold and Mabel Beckman Center for Cancer Immunotherapeutics and Tumor Immunology," stated Ambassador George L. Argyros, chairman of the board of the Arnold and Mabel Beckman Foundation. "The center will dramatically expand the scope of immunotherapy and translational research at City of Hope and will provide a framework for expanding government and private research support. City of Hope continues to better mankind through its translational scientific research. Identified by Dr. Arnold O. Beckman in the early 1980s as one of the nation's leading scientific research institutions, I am confident that he and Mrs. Beckman would be proud to recognize City of Hope with this gift."
The futuristic-looking five-story, 108,000-square-foot center will be designed by architect Ralph E. Johnson, a highly respected designer of science and technology facilities. The first floor of the building will be home to City of Hope's Graduate School of Biological Sciences and include conference and dining facilities for scientific staff. The center will be located in the heart of the City of Hope campus, facilitating contact between investigators and clinicians to move scientific discoveries quickly from the lab to patients. Groundbreaking for the new building is scheduled for early 2007.
The grant to City of Hope builds on two decades of support from the Arnold and Mabel Beckman Foundation. In 1983, the foundation invested $10 million to establish and endow en·dow
tr.v. en·dowed, en·dow·ing, en·dows
1. To provide with property, income, or a source of income.
a. Beckman Research Institute The Beckman Research Institute (BRI) is a research facility affiliated with the City of Hope National Medical Center in Duarte, CA. It is dedicated to studying normal and abnormal biological processes which may be related to cancer. of City of Hope - the first of five such institutes nationwide.
"We are pleased that the Arnold and Mabel Beckman Foundation is continuing its longstanding commitment to scientific discovery at City of Hope," said Andrew Raubitschek, M.D., CITI chair. "This new facility will strengthen our basic science efforts in areas such as tumor immunology, while speeding the outstanding work of our scientists directly to the hands of physicians to benefit patients more quickly than ever before."
The wide array of disciplines represented at the center - from hematology to molecular biology molecular biology, scientific study of the molecular basis of life processes, including cellular respiration, excretion, and reproduction. The term molecular biology was coined in 1938 by Warren Weaver, then director of the natural sciences program at the Rockefeller - will promote collaboration and innovation. CITI researchers will bring together their expertise to focus on four key investigational areas:
--Radioimmunotherapy: Scientists use genetically engineered genetically engineered adjective Recombinant, see there monoclonal antibodies This is a list of monoclonal antibodies, antibodies which are clones of a single parent cell. When used as medications, the generic names end in -mab (see "Nomenclature of monoclonal antibodies"). utilizing methodology developed by Arthur Riggs Dr. Arthur Riggs, Ph.D, is a geneticist who worked with Genentech to express the first artificial gene in bacteria. His work was critical to the modern biotechnology industry because it enabled the large-scale manufacturing of protein drugs, including insulin. , Ph.D., director of Beckman Research Institute at City of Hope. These antibodies carry radioactive isotopes radioactive isotope or radioisotope, natural or artificially created isotope of a chemical element having an unstable nucleus that decays, emitting alpha, beta, or gamma rays until stability is reached. directly to cancerous cells. Antibodies are proteins that seek out specific foreign invaders, such as bacteria, and help destroy them. City of Hope pioneered radioimmunotherapy by developing an antibody that recognizes a marker on the surface of cancer cells cells once believed to be peculiar to cancers, but now know to be epithelial cells differing in no respect from those found elsewhere in the body, and distinguished only by peculiarity of location and grouping.
See also: Cancer , making it useful for targeting tumors.
--Cellular Immunotherapy: Immune cells are genetically reprogrammed to seek out and destroy specific cancers. City of Hope scientists were the first to conduct clinical trials with reprogrammed T-cells to attack lymphoma, neuroblastoma Neuroblastoma Definition
Neuroblastoma is a type of cancer that usually originates either in the tissues of the adrenal gland or in the ganglia of the abdomen or in the ganglia of the nervous system. and glioma glioma /gli·o·ma/ (gli-o´mah) a tumor composed of neuroglia in any of its states of development; sometimes extended to include all intrinsic neoplasms of the brain and spinal cord, as astrocytomas, ependymomas, etc. .
--Molecular Immunotherapy: Researchers studying molecular immunotherapy aim to advance the potential of monoclonal antibodies. Designer proteins are created that fuse two molecules - one seeks out a tumor and the other triggers the immune system to attack the tumor.
--Vaccine Immunotherapy: City of Hope is at the forefront of developing and testing new vaccines that will supercharge su·per·charge
tr.v. su·per·charged, su·per·charg·ing, su·per·charg·es
1. To increase the power of (an engine, for example), as by fitting with a supercharger.
2. the body's immune system against breast, prostate, lung and gastrointestinal cancers.
The Arnold and Mabel Beckman Foundation's $20 million gift is a critical part of City of Hope's $100 million fundraising campaign for the center. Additional gifts include the $15 million anonymous gift, a $2 million bequest bequest: see legacy. from longtime City of Hope supporter Norma Connick and a $1.5 million bequest from longstanding backer Marcelle S. Schwartz.
About the Arnold and Mabel Beckman Foundation
Founded in 1977, the Arnold and Mabel Beckman Foundation makes grants to program-related, nonprofit research institutions to promote research in chemistry and the life sciences, broadly interpreted, and particularly to foster the invention of methods, instruments and materials that will open up new avenues of research in science.
About City of Hope
City of Hope is one of the world's leading research and treatment centers for cancer, diabetes, HIV/AIDS HIV/AIDS Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome and other life-threatening diseases. Named by U.S. News & World Report U.S. News & World Report
Weekly newsmagazine published in Washington, D.C. U.S. News was founded in 1933 by David Lawrence (1888–1973) to cover important domestic events; he founded World Report in 1945 to treat world news. The two magazines were merged in 1948. as one of America's best medical centers for cancer treatment, City of Hope is a Comprehensive Cancer Center, the highest designation bestowed by the National Cancer Institute, and a founding member of the National Comprehensive Cancer Network. Founded in 1913, City of Hope is a pioneer in the fields of bone marrow transplantation Bone Marrow Transplantation Definition
The bone marrow—the sponge-like tissue found in the center of certain bones—contains stem cells that are the precursors of white blood cells, red blood cells, and platelets. and genetics. City of Hope's scientific knowledge is shared with medical centers locally and globally, helping patients battling life-threatening diseases. For more information, visit www.cityofhope.org.